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Reconciling S-LDSC and LDAK functional enrichment estimates

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2019-07-08

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10.1038/s41588-019-0464-1

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Springer Science and Business Media LLC
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Gazal, Steven, Carla Marquez-Luna, Hilary K. Finucane, and Alkes L. Price. 2019. Reconciling S-LDSC and LDAK Functional Enrichment Estimates. Nature Genetics 51, no. 8: 1202-1204.

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Abstract

Recent work has highlighted the importance of accounting for linkage disequilibrium (LD)-dependent genetic architectures in analyses of heritability. Two models incorporating LD-dependent architectures have been proposed for analyses of functional enrichment: the baseline-LD model4 used by stratified LD-score regression (S-LDSC) and the LDAK model.

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Genetics

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https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37371085

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