Publication: Differential Sensitivities of Retroviruses to Integrase Strand Transfer Inhibitors
No Thumbnail Available
Open/View Files
Date
2011
Published Version
Journal Title
Journal ISSN
Volume Title
Publisher
American Society for Microbiology
The Harvard community has made this article openly available. Please share how this access benefits you.
Citation
Koh, Y., K. A. Matreyek, and A. Engelman. 2011. “Differential Sensitivities of Retroviruses to Integrase Strand Transfer Inhibitors.” Journal of Virology 85 (7): 3677–82. https://doi.org/10.1128/jvi.02541-10.
Research Data
Abstract
Integrase inhibitors are emerging anti-human immunodeficiency virus (HIV) drugs, and multiple retroviruses and transposable elements were evaluated here for susceptibilities to raltegravir (RAL) and elvitegravir (EVG). All viruses, including primate and nonprimate lentiviruses, a Betaretrovirus, a Gammaretrovirus, and the Alpharetrovirus Rous sarcoma virus (RSV), were susceptible to inhibition by RAL. EVG potently inhibited all lentiviruses and intermediately inhibited Betaretrovirus and Gammaretrovirus infections yet was basically ineffective against RSV. Substitutions based on HIV type 1 (HIV-1) resistance changes revealed that integrase residue Ser150 contributed significantly to the resistance of RSV. The drugs intermediately inhibited intracisternal A-particle retrotransposition but were inactive against Sleeping Beauty transposition and long interspersed nucleotide element 1 (LINE-1) retrotransposition.
Description
Other Available Sources
Keywords
Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material (LAA), as set forth at Terms of Service