Publication: Dual Function of Ras in Raf Activation
No Thumbnail Available
Date
1998-12-15
Published Version
Journal Title
Journal ISSN
Volume Title
Publisher
The Company of Biologists
The Harvard community has made this article openly available. Please share how this access benefits you.
Citation
Li, Willis X., Michael Melnick, Norbert Perrimon. "Dual Function of Ras in Raf Activation." Development 125, no. 24 (1998): 4999-5008. DOI: 10.1242/dev.125.24.4999
Research Data
Abstract
The small guanine nucleotide binding protein p21(Ras) plays an important role in the activation of the Raf kinase. However, the precise mechanism by which Raf is activated remains unclear. It has been proposed that the sole function of p21(Ras )in Raf activation is to recruit Raf to the plasma membrane. We have used Drosophila embryos to examine the mechanism of Raf (Draf) activation in the complete absence of p21(Ras) (Ras1). We demonstrate that the role of Ras1 in Draf activation is not limited to the translocation of Draf to the membrane through a Ras1-Draf association. In addition, Ras1 is essential for the activation of an additional factor which in turn activates Draf.
Description
Other Available Sources
Keywords
Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material (LAA), as set forth at Terms of Service