A Multifaceted Examination of Cutaneous Disease Associated With Oncologic Conditions: Atypical Post-Radiation Vascular Proliferation, Cutaneous Neoplasms in Lynch Syndrome Patients, Non-Melanoma Skin Cancer in Children, and Case Studies of Rare Cutaneous Eruptions

Abstract

A wide variety of skin conditions can arise in cancer patients, whether from cancer therapy, underlying genetic syndromes, paraneoplastic processes, or immunosuppression. This thesis examines five skin conditions that typically arise in oncologic patients: atypical post-radiation vascular proliferation (APRVP), skin neoplasms in Lynch syndrome, nonmelanoma skin cancers in pediatric patients, dermatomyositis in a patient with EGFR exon 20 mutation non-small cell lung cancer, and atypical erythema multiforme in a patient after bone marrow transplant. The first three studies are multi-institutional retrospective reviews that characterize the demographic and clinical characteristics of the conditions. The last two studies are case reports that suggest a possible pathogenetic mechanism and highlight the importance of recognizing atypical presentations in cancer patients. Through these five studies, this thesis provides insight into risk factors, preventative screening, management, and prognosis of rare cutaneous conditions that may enhance dermatologic care of patients with cancer.