Publication: Synthesis of an electronically-tuned minimally interfering alkynyl photo-affinity label to measure small molecule–protein interactions
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Date
2018-06
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Elsevier BV
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Chang, Mfuh, Gao, Wu, and Woo. "Synthesis of an Electronically-tuned Minimally Interfering Alkynyl Photo-affinity Label to Measure Small Molecule–protein Interactions." Tetrahedron 74, no. 26 (2018): 3273-277.
Abstract
We report the synthesis of an electronically-tuned minimally interfering photo-affinity label (MI-PAL), a compact five-carbon tag functionalized with an alkyl diazirine and alkyne handle. MI-PAL is compatible with protein photo-conjugation, click chemistry and mass spectrometry and readily installed to complex molecules for biological target identification.
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Keywords
photochemistry, diazirine, photo-affinity labeling, chemical proteomics, CuAA, mass spectrometry
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