IG# & IG% in Upper Urinary Tract Infection with Sirs Syndrome Diagnosis, a Retrospective Research at Binh Dan Hospital

Abstract

Introduction: There have been studies examining the application of immature granulocyte counts (IG#) and immature granulocyte percentage (IG%) indexes, especially in the setting of sepsis originating from various sources. However, to the extent of our knowledge, there are no studies on applying these new indices in sepsis originating from the upper urinary tract. Thus, we conduct this research to evaluate the application IG# & IG% in diagnosing sepsis originating from the upper urinary tract at Binh Dan Hospital. Purposes: To investigate the role IG# and IG% in diagnosing sepsis in patients with upper urinary tract infection. Research Methods: A cross-sectional retrospective research of patients diagnosed with sepsis/septic shock caused by upper urinary tract infection, admitted to Binh Dan Hospital from January 1, 2020, to the end of December 31, 2022. Sepsis 2 (1992) was used to classify those patients into two groups: one with systemic inflammatory response syndrome (SIRS) syndrome and the other with SIRS negative. Results: 464 cases met the inclusion criteria. 219 patients had SIRS, of which 19 had positive blood cultures and 226 UTIs without SIRS. Results show that IG# and IG% are valuable tools for the initial screening of sepsis originating from upper urinary tract infections. The sensitivity of IG# was 59.7%, and the specificity was 74.3%at the cut-off point of 0.075 x 103/µL. The sensitivity of IG% was 69.3%, and the specificity was 61.9% at the recommended cut-off point of 0.55. When raising the cut-off point of IG% to 1.95, the specificity was 93%. IG#’s AUC is 0.734, IG%’s AUC is 0.692. Conclusion: Although IG# & IG% cannot be used as a sole biomarker in diagnosing sepsis originating from the upper urinary tract, IG# & IG% are convenient, earliest markers that can help clinicians distinguish between infectious and non-infectious diseases at the time of admission point.