Publication: Fluorescent Vinblastine Probes for Live Cell Imaging
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Date
2016
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Royal Society of Chemistry (RSC)
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Meimetis, Labros G., Randy J. Giedt, Hannes Mikula, Jonathan C. Carlson, Rainer H. Kohler, David B. Pirovich, and Ralph Weissleder. 2016. “Fluorescent Vinblastine Probes for Live Cell Imaging.” Chemical Communications 52 (64): 9953–56. https://doi.org/10.1039/c6cc04129a.
Abstract
Herein we describe the synthesis of several fluorescent analogues of the clinically approved microtubule destabilizing agent vinblastine. The evaluated probes are the most potent described and provides the first example of uptake, distribution and live cell imaging using this well known antimitotic agent.
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