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Processing body autoantibodies reconsidered

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91630 RNA-2006-Bloch-707-9.pdf (425.83 KB)

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2006

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10.1261/rna.17406

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Cold Spring Harbor Laboratory Press
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Bloch, D. B. 2006. “Processing Body Autoantibodies Reconsidered.” RNA 12 (5). Cold Spring Harbor Laboratory: 707–9. doi:10.1261/rna.17406.

Abstract

Processing bodies (P-bodies) are cellular structures that have critical roles in mRNA degradation and post-transcriptional gene silencing. Some patients with autoimmune disease have high titer antibodies directed against P-bodies, and certain sera have been used as markers for the GW182 component of these structures. This study shows that available reference sera are unreliable markers for GW182 because the sera contain antibodies directed against Ge-1, a second P-body autoantigen.

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http://nrs.harvard.edu/urn-3:HUL.InstRepos:41555745

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