IRE1α Activation Protects Mice Against Acetaminophen-Induced Hepatotoxicity

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IRE1α Activation Protects Mice Against Acetaminophen-Induced Hepatotoxicity

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Title: IRE1α Activation Protects Mice Against Acetaminophen-Induced Hepatotoxicity
Author: So, Jae-Seon; Frank-Kamenetsky, Maria; Fitzgerald, Kevin; Koteliansky, Victor; Iwawaki, Takao; Lee, Ann-Hwee; Hur, Kyu Yeon; Glimcher, Laurie Hollis; Ruda, Vera

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Citation: Hur, Kyu Yeon, Jae-Seon So, Vera Ruda, Maria Frank-Kamenetsky, Kevin Fitzgerald, Victor Koteliansky, Takao Iwawaki, Laurie H. Glimcher, and Ann-Hwee Lee. 2012. IRE1α activation protects mice against acetaminophen-induced hepatotoxicity. The Journal of Experimental Medicine 209(2): 307-318.
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Abstract: Mice lacking the transcription factor XBP1 exhibit constitutive activation of the stress sensor IRE1α and are protected from acetaminophen overdose–induced acute liver failure.
Published Version: doi:10.1084/jem.20111298
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280871/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10463939
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