Smoothened regulation in the Hedgehog signaling pathway

DSpace/Manakin Repository

Smoothened regulation in the Hedgehog signaling pathway

Citable link to this page

 

 
Title: Smoothened regulation in the Hedgehog signaling pathway
Author: Nedelcu, Daniel
Citation: Nedelcu, Daniel. 2013. Smoothened regulation in the Hedgehog signaling pathway. Doctoral dissertation, Harvard University.
Full Text & Related Files:
Abstract: Hedgehog signaling is a pathway essential in embryonic development, adult stem cell maintenance, and is implicated in the formation and progression of cancer. Signaling in this pathway is triggered when the secreted protein Hedgehog binds to its membrane receptor, Patched. Patched normally inhibits the seven-spanner transmembrane protein Smoothened (Smo). Binding of Hedgehog inhibits Patched resulting in Smo derepression. Active Smo then triggers the activation of the cytoplasmic steps of the signaling pathway.
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11181143
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters