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dc.contributor.authorGaudet, Rachelle
dc.date.accessioned2013-11-13T16:24:28Z
dc.date.issued2008
dc.identifierQuick submit: 2013-07-15T10:15:32-04:00
dc.identifier.citationGaudet, Rachelle. 2008. TRP channels entering the structural era. The Journal of Physiology 586(15): 3565-3575.en_US
dc.identifier.issn0022-3751en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11315436
dc.description.abstractTransient receptor potential (TRP) channels are important in many neuronal and non-neuronal physiological processes. The past 2 years have seen much progress in the use of structural biology techniques to elucidate molecular mechanisms of TRP channel gating and regulation. Two approaches have proven fruitful: (i) a divide-and-conquer strategy has provided high-resolution structural details of TRP channel fragments although it fails to explain how these fragments are integrated in the full channel; and (ii) electron microscopy of entire TRP channels has yielded low-resolution images that provide a basis for testable models of TRP channel architecture. The results of each approach, summarized in this review, provide a preview of what the future holds in TRP channel structural biology.en_US
dc.description.sponsorshipMolecular and Cellular Biologyen_US
dc.language.isoen_USen_US
dc.publisherWiley Blackwell (Blackwell Publishing -The Physiological Society)en_US
dc.relation.isversionofdoi:10.1113/jphysiol.2008.155812en_US
dash.licenseOAP
dc.subjectIon channelen_US
dc.subjectTRP channelen_US
dc.subjectelect ron microscopyen_US
dc.subjectx-ray crystallographyen_US
dc.titleTRP Channels Entering the Structural Eraen_US
dc.typeJournal Articleen_US
dc.date.updated2013-07-15T14:16:02Z
dc.description.versionAccepted Manuscripten_US
dc.rights.holderRachelle Gaudet
dc.relation.journalThe Journal of Physiologyen_US
dash.depositing.authorGaudet, Rachelle
dc.date.available2013-11-13T16:24:28Z
dc.identifier.doi10.1113/jphysiol.2008.155812*
workflow.legacycommentsIn QSDB.en_US
dash.contributor.affiliatedGaudet, Rachelle


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