Genetic associations with subjective well-being also implicate depression and neuroticism

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Author
Okbay, Aysu
Baselmans, Bart M. L.
De Neve, Jan-Emmanuel
Nivard, Michel G.
Fontana, Mark A.
Meddens, Fleur S. W.
Linnér, Richard Karlsson
Rietveld, Cornelius A.
Derringer, Jaime
Gratten, Jacob
Lee, James J.
Liu, Jimmy Z.
de Vlaming, Ronald
Conley, Dalton C.
Smith, George Davey
Johannesson, Magnus
Medland, Sarah E.
Meyer, Michelle N.
Krueger, Robert F.
Beauchamp, Jonathan Pierre
Koellinger, Philipp D.
Benjamin, Daniel J.
Bartels, Meike
Cesarini, David
Benjamin, Daniel
Bartels, Meike
Koellinger, Philipp
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/ng.3552Metadata
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Okbay, Aysu, Bart M.L. Baselmans, Jan-Emmanuel De Neve, et al.. 2016. Genetic associations with subjective well-being also implicate depression and neuroticism. Nature Genetics 48: 624–633Abstract
We conducted a genome-wide association study of subjective well-being (SWB) in 298,420 individuals. We also performed auxiliary analyses of depressive symptoms (“DS”; N = 161,460) and neuroticism (N = 170,910), both of which have a substantial genetic correlation with SWB (휌̂≈−0.8). We identify three SNPs associated with SWB at genome-wide significance. Two of them are significantly associated with DS in an independent sample. In our auxiliary analyses, we identify 13 additional genome-wide-significant associations: two with DS and eleven with neuroticism, including two inversion polymorphisms. Across our phenotypes, loci regulating expression in central nervous system and adrenal/pancreas tissues are enriched. The discovery of genetic loci associated with the three phenotypes we study has proven elusive; our findings illustrate the payoffs from studying them jointly.Other Sources
http://biorxiv.org/content/early/2015/11/24/032789Terms of Use
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http://nrs.harvard.edu/urn-3:HUL.InstRepos:32303189
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