Enhancing the Therapeutic Efficacy of Cancer Treatment With Cannabinoids

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Author
Mueller, Romy
Sinha, Neeharika
Dabney, Raymond
Herman, Allen
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https://doi.org/10.3389/fonc.2018.00114Metadata
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Yasmin-Karim, Sayeda, Michele Moreau, Romy Mueller, Neeharika Sinha, Raymond Dabney, Allen Herman, and Wilfred Ngwa. 2018. “Enhancing the Therapeutic Efficacy of Cancer Treatment With Cannabinoids.” Frontiers in Oncology 8 (1): 114. doi:10.3389/fonc.2018.00114. http://dx.doi.org/10.3389/fonc.2018.00114.Abstract
Over the years, many in vitro and in vivo studies have shown the antineoplastic effects of cannabinoids (CBDs), with reports advocating for investigations of combination therapy approaches that could better leverage these effects in clinical translation. This study explores the potential of combination approaches employing CBDs with radiotherapy (RT) or smart biomaterials toward enhancing therapeutic efficacy during treatment of pancreatic and lung cancers. In in vitro studies, clonogenic assay results showed greater effective tumor cell killing, when combining CBDs and RT. Meanwhile, in vivo study results revealed major increase in survival when employing smart biomaterials for sustained delivery of CBDs to tumor cells. The significance of these findings, considerations for further research, and viable roadmap to clinical translation are discussed.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928848/pdf/Terms of Use
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