Aortic Stiffness: Review of Life Course, Epidemiology, Risk Factors, and Relevant Biomarkers
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CitationMosarla, Ramya. 2018. Aortic Stiffness: Review of Life Course, Epidemiology, Risk Factors, and Relevant Biomarkers. Doctoral dissertation, Harvard Medical School.
AbstractStiffening of the aorta, as measured by an increase pulse wave velocity has been implicated as a predictor of worsened cardiovascular outcomes and mortality in both general community and high-risk conditions such as diabetes mellitus, chronic kidney disease, hypertension, post-myocardial infarction
and chronic inflammatory disease. In fact, quantification of aortic stiffness by
measuring the carotid-femoral PWV was proposed as an accepted ‘gold standard’ to risk-stratify patients in the management of hypertension. It has also been demonstrated to be a valuable independent predictor of cardiovascular risk. This review discusses the life-course, epidemiology, risk factors and biomarkers related to aortic stiffness.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41973537