(2016) Ha, Jun Yong; Chou, Hui-Ting; Ungar, Daniel; Yip, Calvin K.; Walz, Thomas; Hughson, Frederick M.
The conserved oligomeric Golgi (COG) complex orchestrates vesicular trafficking to and within the Golgi apparatus. Here, we use negative-stain electron microscopy to elucidate the architecture of the hetero-octameric COG complex from Saccharomyces cerevisiae. Intact COG has an intricate shape, with four (or possibly five) flexible legs, that differs strikingly from the exocyst complex and appears well-suited for vesicle capture and fusion.
