(American Diabetes Association, 2008) Fox, Caroline; Pencina, Michael J.; Wilson, Peter W.F.; Paynter, Nina; Vasan, Ramachandran S.; D’Agostino, Ralph B.
Objective: We assessed the lifetime risk of cardiovascular disease (CVD) among individuals with and without obesity and diabetes. Research Design and Methods: Participants were drawn from the original and offspring cohorts of the Framingham Heart Study. Lifetime (30-year) risk of CVD was assessed using a modified Kaplan-Meier approach adjusting for the competing risk of death, beginning from age 50 years. Results: Over 30 years, the lifetime risk of CVD among women with diabetes was 54.8% among normal-weight women and 78.8% among obese women. Among normal-weight men with diabetes, the lifetime risk of CVD was 78.6%, whereas it was 86.9% among obese men. Conclusions: The lifetime risk of CVD among individuals with diabetes is high, and this relationship is further accentuated with increasing adiposity.
