Stress and childhood asthma risk: overlapping evidence from animal studies and epidemiologic research

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Stress and childhood asthma risk: overlapping evidence from animal studies and epidemiologic research

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Title: Stress and childhood asthma risk: overlapping evidence from animal studies and epidemiologic research
Author: Wright, Rosalind Jo
Citation: Wright, Rosalind J. 2008. Stress and childhood asthma risk: overlapping evidence from animal studies and epidemiologic research. Allergy, Asthma, and Clinical Immunology 4(1): 29-36.
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Abstract: Rapidly expanding evidence increasingly strengthens the evidence linking psychological factors to asthma and allergy expression. Parallel studies in animals and humans demonstrating the influence of prenatal maternal stress and early caregiving experiences on the disrupted regulation of defensive biological systems [eg, sympathetic and adrenomedullary (SAM) system and the hypothalamicpituitary-adrenocortical (HPA) axis] provide strong proof of concept for this line of research. The consequent altered neuroimmune responses may influence the expression of immune-mediated disorders such as asthma as well as enhance an individual's susceptibility to other environmental factors that may also contribute to asthma risk.
Published Version: doi:10.1186/1710-1492-4-1-29
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869338/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4878932
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