Cerebrospinal Fluid Biomarkers in Idiopathic Normal Pressure Hydrocephalus
Dello Iacono, Donna
Jääskeläinen, Juha E.
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CitationLeinonen, Ville, Lata G. Menon, Rona S. Carroll, Donna Dello Iacono, Jeremy Grevet, Juha E. Jääskeläinen, and Peter M. Black. 2011. Cerebrospinal fluid biomarkers in idiopathic normal pressure hydrocephalus. International Journal of Alzheimer's Disease 2011(312526).
AbstractThe diagnosis of idiopathic normal pressure hydrocephalus (iNPH) is still challenging. Alzheimer's disease (AD), along with vascular dementia, the most important differential diagnosis for iNPH, has several potential cerebrospinal fluid (CSF) biomarkers which might help in the selection of patients for shunt treatment. The aim of this study was to compare a battery of CSF biomarkers including well-known AD-related proteins with CSF from patients with suspected iNPH collected from the external lumbar drainage test (ELD). A total of 35 patients with suspected iNPH patients were evaluated with ELD. CSF was collected in the beginning of the test, and the concentrations of total tau, ptau181, Aβ42, NFL, TNF-α, TGFβ1, and VEGF were analysed by ELISA. Twenty-six patients had a positive ELD result—that is, their gait symptoms improved; 9 patients had negative ELD. The levels of all analyzed CSF biomarkers were similar between the groups and none of them predicted the ELD result in these patients. Contrary to expectations lumbar CSF TNF-α concentration was low in iNPH patients.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:5266852
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