# Carbon–Fluorine Bond Formation

 Title: Carbon–Fluorine Bond Formation Author: Ritter, Tobias; Furuya, Takeru; Kuttruff, Christian A. Note: Order does not necessarily reflect citation order of authors. Citation: Furuya, Takeru, Christian A. Kuttruff, and Tobias Ritter. 2008. Carbon–fluorine bond formation. Current Opinion in Drug Discovery and Development 11(6): 803–819. Full Text & Related Files: Curr. Opin. Drug Disc. Dev. 2008, 11, 803.pdf (328.5Kb; PDF) Abstract: We present a selection of carbon–fluorine bond formations that have been developed in the recent past. An overview of the most common fluorination reagents is followed by fluorination reactions organized by reactivity. We have distinguished between nucleophilic and electrophilic fluorinations as well as aliphatic and aromatic fluorinations. Each section is divided into more specific reaction classes and examples for syntheses of pharmaceuticals, $$^{18}$$F-radiolabeling, and mechanistic investigations are provided. Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:8301597 Downloads of this work: