Browsing by Author "Greenblatt, Matthew Blake"

Now showing items 1-4 of 4

    • Calcineurin Regulates Innate Antifungal Immunity in Neutrophils 

      Greenblatt, Matthew Blake; Aliprantis, Antonios O.; Hu, Bella; Glimcher, Laurie Hollis (Rockefeller University Press, 2010)
      Patients taking immunosuppressive drugs, like cyclosporine A (CsA), that inhibit calcineurin are highly susceptible to disseminated fungal infections, although it is unclear how these drugs suppress resistance to these ...

    • Graft versus Host Disease in the Bone Marrow, Liver and Thymus Humanized Mouse Model 

      Greenblatt, Matthew Blake; Vbranac, Vladimir; Tivey, Trevor; Tsang, Kelly; Tager, Andrew Martin; Aliprantis, Antonios O. (Public Library of Science, 2012)
      Mice bearing a “humanized” immune system are valuable tools to experimentally manipulate human cells in vivo and facilitate disease models not normally possible in laboratory animals. Here we describe a form of GVHD that ...

    • The microtubule-associated protein DCAMKL1 regulates osteoblast function via repression of Runx2 

      Zou, Weiguo; Greenblatt, Matthew B.; Brady, Nicholas; Lotinun, Sutada; Zhai, Bo; de Rivera, Heather; Singh, Anju; Sun, Jun; Gygi, Steven P.; Baron, Roland; Glimcher, Laurie H.; Jones, Dallas C. (The Rockefeller University Press, 2013)
      Osteoblasts are responsible for the formation and mineralization of the skeleton. To identify novel regulators of osteoblast differentiation, we conducted an unbiased forward genetic screen using a lentiviral-based shRNA ...

    • TAK1 is an Essential Regulator of BMP Signalling in Cartilage 

      Shim, Jae-Hyuck; Greenblatt, Matthew Blake; Xie, Min; Schneider, Michael D; Zou, Weigou; Zhai, Bo; Gygi, Steven P.; Glimcher, Laurie Hollis (Nature Publishing Group, 2009)
      TGFβ activated kinase 1 (TAK1), a member of the MAPKKK family, controls diverse functions ranging from innate and adaptive immune system activation to vascular development and apoptosis. To analyse the in vivo function of ...