Browsing by Author "Salat, David"

Now showing items 1-14 of 14

    • An algorithm for optimal fusion of atlases with different labeling protocols 

      Iglesias, Juan Eugenio; Sabuncu, Mert Rory; Aganj, Iman; Bhatt, Priyanka; Casillas, Christen; Salat, David H.; Boxer, Adam; Fischl, Bruce R.; Van Leemput, Koen (Elsevier BV, 2015)
      In this paper we present a novel label fusion algorithm suited for scenarios in which different manual delineation protocols with potentially disparate structures have been used to annotate the training scans (hereafter ...

    • Automated MRI Measures Identify Individuals with Mild Cognitive Impairment and Alzheimer's Disease 

      Desikan, Rahul S.; Cabral, Howard J.; Hess, Christopher P.; Dillon, William P.; Glastonbury, Christine M.; Weiner, Michael W.; Schmansky, Nicholas J.; Salat, David H.; Greve, Douglas N.; Buckner, Randy Lee; Fischl, Bruce R.; Alzheimer’s Disease Neuroimaging Initiative (Oxford University Press, 2009)
      Mild cognitive impairment can represent a transitional state between normal ageing and Alzheimer's disease. Non-invasive diagnostic methods are needed to identify mild cognitive impairment individuals for early therapeutic ...

    • The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive Individuals 

      Dickerson, Bradford Clark; Bakkour, Akram; Salat, David H.; Feczko, Eric; Pacheco, Jenni; Greve, Douglas N.; Grodstein, Francine; Wright, Christopher Ian; Blacker, Deborah Lynne; Rosas, Herminia Diana; Sperling, Reisa Anne; Atri, Alireza; Growdon, John Herbert; Hyman, Bradley Theodore; Morris, John C.; Fischl, Bruce R.; Buckner, Randy Lee (Oxford University Press, 2009)
      Alzheimer's disease (AD) is associated with neurodegeneration in vulnerable limbic and heteromodal regions of the cerebral cortex, detectable in vivo using magnetic resonance imaging. It is not clear whether abnormalities ...

    • Distinct Functional Networks Within the Cerebellum and Their Relation to Cortical Systems Assessed With Independent Component Analysis 

      Dobromyslin, Vitaly I.; Salat, David; Fortier, Catherine; Leritz, Elizabeth; Beckmann, Christian F.; Milberg, William; McGlinchey, Regina (Elsevier BV, 2012-05-01)
      Cerebellar functional circuitry has been examined in several prior studies using resting fMRI data and seed-based procedures, as well as whole-brain independent component analysis (ICA). Here, we hypothesized that ICA ...

    • Fluid intelligence and brain functional organization in aging yoga and meditation practitioners 

      Gard, Tim; Taquet, Maxime; Dixit, Rohan; Hölzel, Britta K.; de Montjoye, Yves-Alexandre; Brach, Narayan; Salat, David H.; Dickerson, Bradford C.; Gray, Jeremy R.; Lazar, Sara W. (Frontiers Media S.A., 2014)
      Numerous studies have documented the normal age-related decline of neural structure, function, and cognitive performance. Preliminary evidence suggests that meditation may reduce decline in specific cognitive domains and ...

    • Interactive Effects of Apolipoprotein E4 and Diabetes Risk on Later Myelinating White Matter Regions in Neurologically Healthy Older Aged Adults 

      Foley, Jessica M.; Stricker, Nikki H.; Milberg, William; Salat, David; Zink, Tyler; Grande, Laura; McGlinchey, Regina; Leritz, Elizabeth (SAGE Publications, 2013-12-31)
      Possession of the apolipoprotein E4 (APOE4) allele and diabetes risk are independently related to reduced white matter (WM) integrity that may contribute to the development of Alzheimer's disease (AD). The purpose of this ...

    • Military Blast Exposure, Ageing and White Matter Integrity 

      Trotter, Benjamin B.; Robinson, Meghan E.; Milberg, William; Salat, David; McGlinchey, Regina (Oxford University Press (OUP), 2015-06-01)
      Mild traumatic brain injury, or concussion, is associated with a range of neural changes including altered white matter structure. There is emerging evidence that blast exposure-one of the most pervasive causes of casualties ...

    • The nature of white matter abnormalities in blast-related mild traumatic brain injury 

      Hayes, Jasmeet P.; Miller, Danielle R.; Lafleche, Ginette; Salat, David H.; Verfaellie, Mieke (Elsevier, 2015)
      Blast-related traumatic brain injury (TBI) has been a common injury among returning troops due to the widespread use of improvised explosive devices in the Iraq and Afghanistan Wars. As most of the TBIs sustained are in ...

    • Neurobiological Indicators of Disinhibition in Posttraumatic Stress Disorder 

      Sadeh, Naomi; Spielberg, Jeffrey M.; Miller, Mark; Milberg, William; Salat, David; Amick, Melissa M.; Fortier, Catherine; McGlinchey, Regina (Wiley, 2015-08)
      Deficits in impulse control are increasingly recognized in association with posttraumatic stress disorder (PTSD). To our further understanding of the neurobiology of PTSD‐related disinhibition, we examined alterations in ...

    • Reduced Cortical Thickness in Abstinent Alcoholics and Association with Alcoholic Behavior 

      Fortier, Catherine; Leritz, Elizabeth; Salat, David; Venne, Jonathan R.; Maksimovskiy, Arkadiy; Williams, Victoria; Milberg, William; McGlinchey, Regina (Wiley, 2011-12)
      Background Chronic misuse of alcohol results in widespread damage to the brain. Prior morphometric studies have examined cortical atrophy in individuals with alcoholism; however, no previous studies have examined ...

    • Regional White Matter Volume Differences in Nondemented Aging and Alzheimer's Disease 

      Salat, David; Greve, Douglas; Pacheco, Jennifer; Quinn, Brian T.; Helmer, Karl; Buckner, Randy; Fischl, Bruce (Elsevier, 2009)
      Accumulating evidence suggests that altered cerebral white matter (WM) influences normal aging, and further that WM degeneration may modulate the clinical expression of Alzheimer's disease (AD). Here we conducted a study ...

    • The Relationship between Cortical Blood Flow and Sub-Cortical White-Matter Health across the Adult Age Span 

      Chen, J. Jean; Rosas, H. Diana; Salat, David H. (Public Library of Science, 2013)
      Degeneration of cerebral white matter is commonly observed in aging, and the associated degradation in neural connectivity contributes to cognitive decline in older adults. Vascular dysfunction has been implicated as a ...

    • Selective Disruption of the Cerebral Neocortex in Alzheimer's Disease 

      Desikan, Rahul S.; Schmansky, Nicholas J.; Cabral, Howard J.; Hess, Christopher P.; Weiner, Michael W.; Kemper, Thomas L.; Dale, Anders M.; Sabuncu, Mert R; the Alzheimer’s Disease Neuroimaging Initiative; Reuter, Martin; Biffi, Alessandro; Anderson, Christopher David; Rosand, Jonathan; Salat, David H.; Sperling, Reisa Anne; Fischl, Bruce R. (Public Library of Science, 2010)
      Background: Alzheimer's disease (AD) and its transitional state mild cognitive impairment (MCI) are characterized by amyloid plaque and tau neurofibrillary tangle (NFT) deposition within the cerebral neocortex and neuronal ...

    • Widespread Effects of Alcohol on White Matter Microstructure 

      Fortier, Catherine; Leritz, Elizabeth; Salat, David; Lindemer, Emily R.; Maksimovskiy, Arkadiy; Shepel, Juli; Williams, Victoria; Venne, Jonathan R.; Milberg, William; McGlinchey, Regina (Wiley, 2014-12)
      Background Evidence suggests that chronic misuse of alcohol may preferentially affect the integrity of frontal white matter tracts, which can impact executive functions important to achieve and maintain abstinence. M ...