Browsing Faculty of Arts and Sciences by Keyword "anhedonia"
Now showing items 1-8 of 8
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Acute Stress Selectively Reduces Reward Sensitivity
(Frontiers Research Foundation, 2013)Stress may promote the onset of psychopathology by disrupting reward processing. However, the extent to which stress impairs reward processing, rather than incentive processing more generally, is unclear. To evaluate the ... -
Childhood Adversity is Associated with Left Basal Ganglia Dysfunction During Reward Anticipation in Adulthood
(Elsevier, 2009)Background: Childhood adversity increases the risk of psychopathology, but the neurobiological mechanisms underlying this vulnerability are not well-understood. In animal models, early adversity is associated with dysfunction ... -
Euthymic Patients with Bipolar Disorder Show Decreased Reward Learning in a Probabilistic Reward Task
(Elsevier, 2008)Background: Bipolar disorder (BPD) features cycling mood states ranging from depression to mania with intermittent phases of euthymia. Bipolar disorder subjects often show excessive goal-directed and pleasure-seeking ... -
Increased Perceived Stress is Associated with Blunted Hedonic Capacity: Potential Implications for Depression Research
(Elsevier Science, 2007)Preclinical studies suggest that stress exerts depressogenic effects by impairing hedonic capacity, in humans, however, the precise mechanisms linking stress and depression are largely unknown. As an initial step towards ... -
Reduced Hedonic Capacity in Major Depressive Disorder: Evidence from a Probabilistic Reward Task
(Elsevier, 2008)Objective: Anhedonia, the lack of reactivity to pleasurable stimuli, is a cardinal feature of depression that has received renewed interest as a potential endophenotype of this debilitating disease. The goal of the ... -
The Role of the Nucleus Accumbens and Rostral Anterior Cingulate Cortex in Anhedonia: Integration of Resting EEG, fMRI, and Volumetric Techniques
(Elsevier, 2006)Anhedonia, the reduced propensity to experience pleasure, is a promising endo-- phenotype and vulnerability factor for several psychiatric disorders, including depression and schizophrenia. In the present study, we used ... -
A Single Dose of Nicotine Enhances Reward Responsiveness in Nonsmokers: Implications for Development of Dependence
(Elsevier, 2008)Background: Tobacco smoking, driven by the addictive properties of nicotine, is the most prevalent preventable cause of death in the Western world. Accumulated evidence suggests that nicotine may increase appetitive ... -
Toward an Objective Characterization of an Anhedonic Phenotype: A Signal-Detection Approach
(Elsevier, 2005)Background: Difficulties in defining and characterizing phenotypes has hindered progress in psychiatric genetics and clinical neuroscience. Decreased approach-related behavior and anhedonia (lack of responsiveness to ...