dc.contributor.author | Buzon, Maria J. | en_US |
dc.contributor.author | Sun, Hong | en_US |
dc.contributor.author | Li, Chun | en_US |
dc.contributor.author | Shaw, Amy | en_US |
dc.contributor.author | Seiss, Katherine | en_US |
dc.contributor.author | Ouyang, Zhengyu | en_US |
dc.contributor.author | Martin-Gayo, Enrique | en_US |
dc.contributor.author | Leng, Jin | en_US |
dc.contributor.author | Henrich, Timothy J. | en_US |
dc.contributor.author | Li, Jonathan Z. | en_US |
dc.contributor.author | Pereyra, Florencia | en_US |
dc.contributor.author | Zurakowski, Ryan | en_US |
dc.contributor.author | Walker, Bruce D. | en_US |
dc.contributor.author | Rosenberg, Eric S. | en_US |
dc.contributor.author | Yu, Xu G. | en_US |
dc.contributor.author | Lichterfeld, Mathias | en_US |
dc.date.accessioned | 2014-09-08T15:35:51Z | |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | Buzon, M. J., H. Sun, C. Li, A. Shaw, K. Seiss, Z. Ouyang, E. Martin-Gayo, et al. 2014. “HIV-1 persistence in CD4+ T cells with stem cell-like properties.” Nature medicine 20 (2): 139-142. doi:10.1038/nm.3445. http://dx.doi.org/10.1038/nm.3445. | en |
dc.identifier.issn | 1078-8956 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:12785806 | |
dc.description.abstract | Cellular HIV-1 reservoirs that persist despite antiretroviral treatment are incompletely defined. We show that during suppressive antiretroviral therapy, CD4+ T memory stem cells (TSCM) harbor high per-cell levels of HIV-1 DNA, and make increasing contributions to the total viral CD4+ T cell reservoir over time. Moreover, phylogenetic studies suggested long-term persistence of viral quasispecies in CD4+ TSCM cells. Thus, HIV-1 may exploit stem cell characteristics of cellular immune memory to promote long-term viral persistence. | en |
dc.language.iso | en_US | en |
dc.relation.isversionof | doi:10.1038/nm.3445 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959167/pdf/ | en |
dash.license | LAA | en_US |
dc.title | HIV-1 persistence in CD4+ T cells with stem cell-like properties | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Nature medicine | en |
dash.depositing.author | Henrich, Timothy J. | en_US |
dc.date.available | 2014-09-08T15:35:51Z | |
dc.identifier.doi | 10.1038/nm.3445 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Li, Jonathan | |
dash.contributor.affiliated | Henrich, Timothy J. | |
dash.contributor.affiliated | Pereyra, F | |
dash.contributor.affiliated | Lichterfeld, Mathias | |
dash.contributor.affiliated | Rosenberg, Eric | |
dash.contributor.affiliated | Walker, Bruce | |
dc.identifier.orcid | 0000-0001-6122-9245 | |