dc.contributor.author | Fay, André P | en_US |
dc.contributor.author | Signoretti, Sabina | en_US |
dc.contributor.author | Callea, Marcella | en_US |
dc.contributor.author | Telό, Gabriela H | en_US |
dc.contributor.author | McKay, Rana R | en_US |
dc.contributor.author | Song, Jiaxi | en_US |
dc.contributor.author | Carvo, Ingrid | en_US |
dc.contributor.author | Lampron, Megan E | en_US |
dc.contributor.author | Kaymakcalan, Marina D | en_US |
dc.contributor.author | Poli-de-Figueiredo, Carlos E | en_US |
dc.contributor.author | Bellmunt, Joaquim | en_US |
dc.contributor.author | Hodi, F Stephen | en_US |
dc.contributor.author | Freeman, Gordon J | en_US |
dc.contributor.author | Elfiky, Aymen | en_US |
dc.contributor.author | Choueiri, Toni K | en_US |
dc.date.accessioned | 2015-04-01T15:30:03Z | |
dc.date.issued | 2015 | en_US |
dc.identifier.citation | Fay, A. P., S. Signoretti, M. Callea, G. H. Telό, R. R. McKay, J. Song, I. Carvo, et al. 2015. “Programmed death ligand-1 expression in adrenocortical carcinoma: an exploratory biomarker study.” Journal for Immunotherapy of Cancer 3 (1): 3. doi:10.1186/s40425-015-0047-3. http://dx.doi.org/10.1186/s40425-015-0047-3. | en |
dc.identifier.issn | 2051-1426 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:14351221 | |
dc.description.abstract | Background: Adrenocortical carcinoma (ACC) is a rare tumor in which prognostic factors are still not well established. Programmed Death Ligand-1 (PD-L1) expression in ACC and its association with clinico-pathological features and survival outcomes are unknown. Methods: Formalin-fixed paraffin-embedded (FFPE) specimens were obtained from 28 patients with ACC. PD-L1 expression was evaluated by immunohistochemistry (IHC) in both tumor cell membrane and tumor infiltrating mononuclear cells (TIMC). PD-L1 positivity on tumor cells was defined as ≥5% tumor cell membrane staining. TIMC were evaluated by IHC using a CD45 monoclonal antibody. For PD-L1 expression in TIMC, a combined score based on the extent of infiltrates and percentage of positive cells was developed. Any score greater that zero was considered PD-L1 positive. Baseline clinico-pathological characteristics and follow up data were retrospectively collected. Comparisons between PD-L1 expression and clinico-pathological features were evaluated using unpaired t-test and Fisher’s exact test. Kaplan-Meier method and log-rank test were used to assess association between PD-L1 expression and 5-year overall survival (OS). Results: Among 28 patients with surgically treated ACC, 3 (10.7%) were considered PD-L1 positive on tumor cell membrane. On the other hand, PD-L1 expression in TIMC was performed in 27 specimens and PD-L1 positive staining was observed in 19 (70.4%) patients. PD-L1 positivity in either tumor cell membrane or TIMC was not significantly associated with higher stage at diagnosis, higher tumor grade, excessive hormone secretion, or OS. Conclusions: PD-L1 expression can exist in ACC in both tumor cell membrane and TIMC with no relationship to clinico-pathologic parameters or survival. Electronic supplementary material The online version of this article (doi:10.1186/s40425-015-0047-3) contains supplementary material, which is available to authorized users. | en |
dc.language.iso | en_US | en |
dc.publisher | BioMed Central | en |
dc.relation.isversionof | doi:10.1186/s40425-015-0047-3 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357210/pdf/ | en |
dash.license | LAA | en_US |
dc.subject | Adrenocortical carcinoma | en |
dc.subject | PD-L1 | en |
dc.subject | PD-1 inhibitors | en |
dc.subject | Immunotherapy | en |
dc.title | Programmed death ligand-1 expression in adrenocortical carcinoma: an exploratory biomarker study | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Journal for Immunotherapy of Cancer | en |
dash.depositing.author | Signoretti, Sabina | en_US |
dc.date.available | 2015-04-01T15:30:03Z | |
dc.identifier.doi | 10.1186/s40425-015-0047-3 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Elfiky, Aymen | |
dash.contributor.affiliated | Choueiri, Toni | |
dash.contributor.affiliated | Bellmunt, Joaquim | |
dash.contributor.affiliated | Freeman, Gordon | |
dash.contributor.affiliated | Signoretti, Sabina | |