Browsing FAS Scholarly Articles by FAS Department "Chemistry and Chemical Biology"
Now showing items 21-40 of 1044
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All-Atom Model for Stabilization of α-Helical Structure in Peptides by Hydrocarbon Staples
(American Chemical Society (ACS), 2009)Recent work has shown that the incorporation of an all-hydrocarbon “staple” into peptides can greatly increase their α-helix propensity, leading to an improvement in pharmaceutical properties such as proteolytic stability, ... -
All-Optical Interrogation of Neural Circuits
(Society for Neuroscience, 2015)There have been two recent revolutionary advances in neuroscience: First, genetically encoded activity sensors have brought the goal of optical detection of single action potentials in vivo within reach. Second, optogenetic ... -
Allene Synthesis from 2-Alkyn-1-Ols
(Elsevier, 1989)Activation of 2-alkyn-1-01s as their methanesulfonate esters and displacement with hydrazine urnishes the corresponding alkynyl hydrazine derivatives which undergo smooth oxidative rearrangement with diethyl azodicarboxylate ... -
Allosteric Communication in Myosin V: From Small Conformational Changes to Large Directed Movements
(Public Library of Science, 2008)The rigor to post-rigor transition in myosin, a consequence of ATP binding, plays an essential role in the Lymn–Taylor functional cycle because it results in the dissociation of the actomyosin complex after the powerstroke. ... -
Alternating layer addition approach to CdSe/CdS core/shell quantum dots with near-unity quantum yield and high on-time fractions
(Royal Society of Chemistry (RSC), 2012)We report single-particle photoluminescence (PL) intermittency (blinking) with high on-time fractions in colloidal CdSe quantum dots (QD) with conformal CdS shells of 1.4 nm thickness, equivalent to approximately 4 CdS ... -
Amino Acid Metabolic Origin as an Evolutionary Influence on Protein Sequence in Yeast
(Springer-Verlag, 2009)The metabolic cycle of Saccharomyces cerevisiae consists of alternating oxidative (respiration) and reductive (glycolysis) energy-yielding reactions. The intracellular concentrations of amino acid precursors generated by ... -
Analog Modeling of Worm-Like Chain Molecules Using Macroscopic Beads-on-a-String
(Royal Society of Chemistry (RSC), 2012)This paper describes an empirical model of polymer dynamics, based on the agitation of millimeter-sized polymeric beads. Although the interactions between the particles in the macroscopic model, and those between the ... -
Analysis of Inorganic Polyphosphates by Capillary Gel Electrophoresis
(American Chemical Society, 2010)This paper describes the development of a method that uses capillary gel electrophoresis (CGE) to analyze mixtures of inorganic polyphosphate ((P\(_i\))\(_n\)). Resolution of (P\(_i\))\(_n\) on the basis of n, the number ... -
Analytical Devices Based on Direct Synthesis of DNA on Paper
(American Chemical Society (ACS), 2016)This paper addresses a growing need in clinical diagnostics for parallel, multiplex analysis of biomarkers from small biological samples. It describes a new procedure for assembling microarrays of ssDNA and proteins on ... -
Analytical nuclear gradients for the range-separated many-body dispersion model of noncovalent interactions
(Royal Society of Chemistry (RSC), 2016)An accurate treatment of the long-range electron correlation energy, including van der Waals (vdW) or dispersion interactions, is essential for describing the structure, dynamics, and function of a wide variety of systems. ... -
Analyzing Forensic Evidence Based on Density with Magnetic Levitation
(Wiley-Blackwell, 2013)This paper describes a method for determining the density of contact trace objects with magnetic levitation (MagLev). MagLev measurements accurately determine the density (±0.0002 g/cm3) of a diamagnetic object and are ... -
Anion Stabilization in Electrostatic Environments
(American Chemical Society, 2011)Excess charge stabilization of molecules in metallic environments is of particular importance for fields such as molecular electronics and surface chemistry. We study the energetics of benzene and its anion between two ... -
Anomalously Rapid Tunneling: Charge Transport across Self-Assembled Monolayers of Oligo(ethylene glycol)
(American Chemical Society (ACS), 2017)This paper describes charge transport by tunneling across self-assembled monolayers (SAMs) of thiol-terminated derivatives of oligo(ethylene glycol) (HS(CH2CH2O)nCH3; HS(EG)nCH3); these SAMs are positioned between gold ... -
Anti-Brownian Traps for Studies on Single Molecules
(Elsevier BV, 2010)Until recently, Brownian motion was seen as an immutable feature of small particles in room-temperature liquids. Molecules, viruses, organelles, and small cells jiggle incessantly due to countless collisions with thermally ... -
Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones
(Nature Publishing Group, 2014)Despite decades of speculation that inhibiting endogenous insulin degradation might treat type-2 diabetes, and the identification of IDE (insulin-degrading enzyme) as a diabetes susceptibility gene, the relationship between ... -
Antilocalization of Coulomb Blockade in a Ge/Si Nanowire
(American Physical Society (APS), 2014)The distribution of Coulomb blockade peak heights as a function of magnetic field is investigated experimentally in a Ge/Si nanowire quantum dot. Strong spin-orbit coupling in this hole-gas system leads to antilocalization ... -
Antimony-doped Tin(II) Sulfide Thin Films
(American Chemical Society, 2012-12-07)Thin-film solar cells made from earth-abundant, inexpensive, and nontoxic materials are needed to replace the current technologies whose widespread use is limited by their use of scarce, costly, and toxic elements. Tin ... -
Application of a Catalytic Asymmetric Povarov Reaction using Chiral Ureas to the Synthesis of a Tetrahydroquinoline Library
(American Chemical Society, 2012)A 2328-membered library of 2,3,4-trisubstituted tetrahydroquinolines was produced using a combination of solution- and solid-phase synthesis techniques. A tetrahydroquinoline (THQ) scaffold was prepared via an asymmetric ... -
Application of Compressed Sensing to the Simulation of Atomic Systems
(Proceedings of the National Academy of Sciences, 2012)Compressed sensing is a method that allows a significant reduction in the number of samples required for accurate measurements in many applications in experimental sciences and engineering. In this work, we show that ... -
Application of Palladium-Mediated 18F-Fluorination to PET Radiotracer Development: Overcoming Hurdles to Translation
(Public Library of Science, 2013)New chemistry methods for the synthesis of radiolabeled small molecules have the potential to impact clinical positron emission tomography (PET) imaging, if they can be successfully translated. However, progression of ...