Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer
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Author
Jarvis, David
Mitchell, Jonathan S
Law, Philip J
Palin, Kimmo
Tuupanen, Sari
Gylfe, Alexandra
Hänninen, Ulrika A
Cajuso, Tatiana
Tanskanen, Tomas
Kondelin, Johanna
Kaasinen, Eevi
Sarin, Antti-Pekka
Kaprio, Jaakko
Eriksson, Johan G
Rissanen, Harri
Knekt, Paul
Pukkala, Eero
Jousilahti, Pekka
Salomaa, Veikko
Ripatti, Samuli
Järvinen, Heikki
Renkonen-Sinisalo, Laura
Lepistö, Anna
Böhm, Jan
Meklin, Jukka-Pekka
Al-Tassan, Nada A
Palles, Claire
Martin, Lynn
Barclay, Ella
Farrington, Susan M
Timofeeva, Maria N
Meyer, Brian F
Wakil, Salma M
Campbell, Harry
Smith, Christopher G
Idziaszczyk, Shelley
Maughan, Timothy S
Kaplan, Richard
Kerr, Rachel
Kerr, David
Buchanan, Daniel D
Win, Aung K
Hopper, John L
Jenkins, Mark A
Lindor, Noralane M
Newcomb, Polly A
Gallinger, Steve
Conti, David
Schumacher, Fred
Casey, Graham
Taipale, Jussi
Aaltonen, Lauri A
Cheadle, Jeremy P
Dunlop, Malcolm G
Tomlinson, Ian P
Houlston, Richard S
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/bjc.2016.188Metadata
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Jarvis, D., J. S. Mitchell, P. J. Law, K. Palin, S. Tuupanen, A. Gylfe, U. A. Hänninen, et al. 2016. “Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer.” British Journal of Cancer 115 (2): 266-272. doi:10.1038/bjc.2016.188. http://dx.doi.org/10.1038/bjc.2016.188.Abstract
Background: Observational studies have associated adiposity with an increased risk of colorectal cancer (CRC). However, such studies do not establish a causal relationship. To minimise bias from confounding we performed a Mendelian randomisation (MR) analysis to examine the relationship between adiposity and CRC. Methods: We used SNPs associated with adult body mass index (BMI), waist-hip ratio (WHR), childhood obesity and birth weight as instrumental variables in a MR analysis of 9254 CRC cases and 18 386 controls. Results: In the MR analysis, the odds ratios (ORs) of CRC risk per unit increase in BMI, WHR and childhood obesity were 1.23 (95% CI: 1.02–1.49, P=0.033), 1.59 (95% CI: 1.08–2.34, P=0.019) and 1.07 (95% CI: 1.03–1.13, P=0.018), respectively. There was no evidence for association between birth weight and CRC (OR=1.22, 95% CI: 0.89–1.67, P=0.22). Combining these data with a concurrent MR-based analysis for BMI and WHR with CRC risk (totalling to 18 190 cases, 27 617 controls) provided increased support, ORs for BMI and WHR were 1.26 (95% CI: 1.10–1.44, P=7.7 × 10−4) and 1.40 (95% CI: 1.14–1.72, P=1.2 × 10−3), respectively. Conclusions: These data provide further evidence for a strong causal relationship between adiposity and the risk of developing CRC highlighting the urgent need for prevention and treatment of adiposity.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947703/pdf/Terms of Use
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