Light Controlled Modulation of Gene Expression by Chemical Optoepigenetic Probes
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Author
Reis, Surya A.
Ghosh, Balaram
Hendricks, J. Adam
Szantai-Kis, D. Miklos
Törk, Lisa
Lamb, Justin
Read-Button, Willis
Zheng, Baixue
Wang, Hongtao
Salthouse, Christopher
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1038/nchembio.2042Metadata
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Reis, S. A., B. Ghosh, J. A. Hendricks, D. M. Szantai-Kis, L. Törk, K. N. Ross, J. Lamb, et al. 2016. “Light Controlled Modulation of Gene Expression by Chemical Optoepigenetic Probes.” Nature chemical biology 12 (5): 317-323. doi:10.1038/nchembio.2042. http://dx.doi.org/10.1038/nchembio.2042.Abstract
Epigenetic gene regulation is a dynamic process orchestrated by chromatin-modifying enzymes. Many of these master regulators exert their function through covalent modification of DNA and histone proteins. Aberrant epigenetic processes have been implicated in the pathophysiology of multiple human diseases. Small-molecule inhibitors have been essential to advancing our understanding of the underlying molecular mechanisms of epigenetic processes. However, the resolution offered by small molecules is often insufficient to manipulate epigenetic processes with high spatio-temporal control. Here, we present a novel and generalizable approach, referred to as ‘Chemo-Optical Modulation of Epigenetically-regulated Transcription’ (COMET), enabling high-resolution, optical control of epigenetic mechanisms based on photochromic inhibitors of human histone deacetylases using visible light. COMET probes may translate into novel therapeutic strategies for diseases where conditional and selective epigenome modulation is required.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836974/pdf/Terms of Use
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