dc.contributor.author | Mendivil, C. O. | |
dc.contributor.author | Rimm, Eric Bruce | |
dc.contributor.author | Furtado, Jeremy Daniel | |
dc.contributor.author | Chiuve, Stephanie Elizabeth | |
dc.contributor.author | Sacks, Frank Martin | |
dc.date.accessioned | 2017-01-26T21:20:15Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Mendivil, C. O., E. B. Rimm, J. Furtado, S. E. Chiuve, and F. M. Sacks. 2011. “Low-Density Lipoproteins Containing Apolipoprotein C-III and the Risk of Coronary Heart Disease.” Circulation 124 (19) (October 10): 2065–2072. doi:10.1161/circulationaha.111.056986. | en_US |
dc.identifier.issn | 1932-6203 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:30147221 | |
dc.description.abstract | BACKGROUND:
Low-density lipoprotein (LDL) that contains apolipoprotein (apo) C-III makes up only 10% to 20% of plasma LDL but has a markedly altered metabolism and proatherogenic effects on vascular cells.
METHODS AND RESULTS:
We examined the association between plasma LDL with apoC-III and coronary heart disease in 320 women and 419 men initially free of cardiovascular disease who developed a fatal or nonfatal myocardial infarction during 10 to 14 years of follow-up and matched controls who remained free of coronary heart disease. Concentrations of LDL with apoC-III (measured as apoB in this fraction) were associated with risk of coronary heart disease in multivariable analysis that included the ratio of total cholesterol to high-density lipoprotein cholesterol, LDL cholesterol, apoB, triglycerides, or high-density lipoprotein cholesterol and other risk factors. In all models, the relative risks for the top versus bottom quintile of LDL with apoC-III were greater than those for LDL without apoC-III. When included in the same multivariable-adjusted model, the risk associated with LDL with apoC-III (relative risk for top versus bottom quintile, 2.38; 95% confidence interval, 1.54-3.68; P for trend <0.001) was significantly greater than that associated with LDL without apoC-III (relative risk for top versus bottom quintile, 1.25; 95% confidence interval, 0.76-2.05; P for trend=0.97; P for interaction <0.001). This divergence in association with coronary heart disease persisted even after adjustment for plasma triglycerides.
CONCLUSIONS:
The risk of coronary heart disease contributed by LDL appeared to result to a large extent from LDL that contains apoC-III. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Ovid Technologies (Wolters Kluwer Health) | en_US |
dc.relation.isversionof | doi:10.1371/journal.pone.0114859 | en_US |
dc.relation.hasversion | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244212/ | en_US |
dash.license | LAA | |
dc.subject | apolipoproteins | en_US |
dc.subject | risk factors | en_US |
dc.subject | metabolism | en_US |
dc.subject | cholesterol | en_US |
dc.subject | myocardial infarction | en_US |
dc.title | Low-Density Lipoproteins Containing Apolipoprotein C-III and the Risk of Coronary Heart Disease | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Accepted Manuscript | en_US |
dc.relation.journal | Circulation | en_US |
dash.depositing.author | Sacks, Frank Martin | |
dc.date.available | 2017-01-26T21:20:15Z | |
dc.identifier.doi | 10.1371/journal.pone.0114859 | * |
dash.contributor.affiliated | Chiuve, Stephanie | |
dash.contributor.affiliated | Furtado, Jeremy | |
dash.contributor.affiliated | Sacks, Frank | |
dash.contributor.affiliated | Rimm, Eric | |