Browsing Harvard Medical School by Author "Lensch, M. William"

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    • Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition 

      Kim, Peter Geon; Albacker, Colleen E.; Lu, Yi-fen; Jang, Il-ho; Lim, Yoowon; Heffner, Garrett C.; Arora, Natasha; Bowman, Teresa V.; Lin, Michelle I.; Lensch, M. William; Angeles, Alejandro Los; Zon, Leonard I.; Loewer, Sabine; Daley, George Q. (National Academy of Sciences, 2013)
      During development, the hematopoietic lineage transits through hemogenic endothelium, but the signaling pathways effecting this transition are incompletely characterized. Although the Hedgehog (Hh) pathway is hypothesized ...