Browsing Harvard Medical School by Author "Lifson, Jeffrey D."

Now showing items 1-5 of 5

    • AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges 

      Gardner, Matthew R.; Kattenhorn, Lisa M.; Kondur, Hema R.; von Schaewen, Markus; Dorfman, Tatyana; Chiang, Jessica J.; Haworth, Kevin G.; Decker, Julie M.; Alpert, Michael D.; Bailey, Charles C.; Neale, Ernest S.; Fellinger, Christoph H.; Joshi, Vinita R.; Fuchs, Sebastian P.; Martinez-Navio, Jose M.; Quinlan, Brian D.; Yao, Annie Y.; Mouquet, Hugo; Gorman, Jason; Zhang, Baoshan; Poignard, Pascal; Nussenzweig, Michel C.; Burton, Dennis R.; Kwong, Peter D.; Piatak, Michael; Lifson, Jeffrey D.; Gao, Guangping; Desrosiers, Ronald C.; Evans, David T.; Hahn, Beatrice H.; Ploss, Alexander; Cannon, Paula M.; Seaman, Michael S.; Farzan, Michael (2015)
      Long-term in vivo expression of a broad and potent entry inhibitor could circumvent the need for a conventional vaccine for HIV-1. Adeno-associated virus (AAV) vectors can stably express HIV-1 broadly neutralizing antibodies ...

    • ADCC Develops Over Time during Persistent Infection with Live-Attenuated SIV and Is Associated with Complete Protection against \(SIV_{mac}251\) Challenge 

      Alpert, Michael D.; Harvey, Jackson D.; Piatak, Michael; Carville, Angela; Lifson, Jeffrey D.; Li, Wenjun; Lauer, William A.; Reeves, Roger Keith; Mansfield, Keith G.; Desrosiers, Ronald C.; Johnson, R. Paul; Evans, David T. (Public Library of Science, 2012)
      Live-attenuated strains of simian immunodeficiency virus (SIV) routinely confer apparent sterilizing immunity against pathogenic SIV challenge in rhesus macaques. Understanding the mechanisms of protection by live-attenuated ...

    • Gp120 on HIV-1 Virions Lacks O-Linked Carbohydrate 

      Stansell, Elizabeth; Panico, Maria; Canis, Kevin; Pang, Poh-Choo; Bouché, Laura; Binet, Daniel; O'Connor, Michael-John; Chertova, Elena; Bess, Julian; Lifson, Jeffrey D.; Haslam, Stuart M.; Morris, Howard R.; Desrosiers, Ronald C.; Dell, Anne (Public Library of Science, 2015)
      As HIV-1-encoded envelope protein traverses the secretory pathway, it may be modified with N- and O-linked carbohydrate. When the gp120s of HIV-1 NL4-3, HIV-1 YU2, HIV-1 Bal, HIV-1 JRFL, and HIV-1 JRCSF were expressed as ...

    • Location and Dynamics of the Immunodominant CD8 T Cell Response to SIVΔnef Immunization and SIVmac251 Vaginal Challenge 

      Sasikala-Appukuttan, Arun K.; Kim, Hyeon O.; Kinzel, Nikilyn J.; Hong, Jung Joo; Smith, Anthony J.; Wagstaff, Reece; Reilly, Cavan; Piatak, Michael; Lifson, Jeffrey D.; Reeves, R. Keith; Johnson, R. Paul; Haase, Ashley T.; Skinner, Pamela J. (Public Library of Science, 2013)
      Live-attenuated SIV vaccines (LAVs) have been the most effective to date in preventing or partially controlling infection by wild-type SIV in non-human primate models of HIV-1 transmission to women acting by mechanisms of ...

    • Loss of CD103+ DCs and Mucosal IL-17+ and IL-22+ Lymphocytes is Associated with Mucosal Damage in SIV Infection 

      Klatt, Nichole R.; Estes, Jacob D.; Sun, Xiaoyong; Ortiz, Alexandra M.; Barber, John S.; Harris, Levelle D.; Cervasi, Barbara; Yokomizo, Lauren K.; Pan, Li; Vinton, Carol L.; Tabb, Brian; Canary, Lauren A.; Dang, Que; Hirsch, Vanessa M.; Alter, Galit; Belkaid, Yasmine; Lifson, Jeffrey D.; Silvestri, Guido; Milner, Joshua D.; Paiardini, Mirko; Haddad, Elias K.; Brenchley, Jason M. (2012)
      HIV/SIV disease progression is associated with multifocal damage to the GI tract epithelial barrier that correlates with microbial translocation and persistent pathological immune activation but the underlying mechanisms ...