Browsing Harvard Medical School by Author "Blakemore, Colin"
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Wheel Running from a Juvenile Age Delays Onset of Specific Motor Deficits but does not Alter Protein Aggregate Density in a Mouse Model of Huntington's Disease
van Dellen, Anton; Cordery, Patricia M; Spires, Tara L.; Blakemore, Colin; Hannan, Anthony J (BioMed Central, 2008)Background: Huntington's disease (HD) is a neurodegenerative disorder predominantly affecting the cerebral cortex and striatum. Transgenic mice (R6/1 line), expressing a CAG repeat encoding an expanded polyglutamine tract ...