Browsing Harvard Medical School by Author "Alter, Galit"

Now showing items 1-6 of 6

    • Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination 

      Mahan, Alison E.; Jennewein, Madeleine F.; Suscovich, Todd; Dionne, Kendall; Tedesco, Jacquelynne; Chung, Amy W.; Streeck, Hendrik; Pau, Maria; Schuitemaker, Hanneke; Francis, Don; Fast, Patricia; Laufer, Dagna; Walker, Bruce D.; Baden, Lindsey; Barouch, Dan H.; Alter, Galit (Public Library of Science, 2016)
      Antibody effector functions, such as antibody-dependent cellular cytotoxicity, complement deposition, and antibody-dependent phagocytosis, play a critical role in immunity against multiple pathogens, particularly in the ...

    • Chronic HCV Infection Affects the NK Cell Phenotype in the Blood More than in the Liver 

      Cosgrove, Cormac; Berger, Christoph T.; Kroy, Daniela C.; Cheney, Patrick C.; Ghebremichael, Musie; Aneja, Jasneet; Tomlinson, Michelle; Kim, Arthur Y.; Lauer, Georg M.; Alter, Galit (Public Library of Science, 2014)
      Although epidemiological and functional studies have implicated NK cells in protection and early clearance of HCV, the mechanism by which they may contribute to viral control is poorly understood, particularly at the site ...

    • Differential Levels of Soluble Inflammatory Markers by Human Immunodeficiency Virus Controller Status and Demographics 

      Li, Jonathan Z.; Arnold, Kelly B.; Lo, Janet; Dugast, Anne-Sophie; Plants, Jill; Ribaudo, Heather J.; Cesa, Kevin; Heisey, Andrea; Kuritzkes, Daniel R.; Lauffenburger, Douglas A.; Alter, Galit; Landay, Alan; Grinspoon, Steven; Pereyra, Florencia (Oxford University Press, 2014)
      Background. Human immunodeficiency virus (HIV)-1 elite controllers (ECs) represent an ideal population to study the effects of HIV persistence on chronic inflammation in the absence of antiretroviral therapy (ART). Methods. ...

    • Enhanced binding of antibodies generated during chronic HIV infection to mucus component MUC16 

      Gunn, Bronwyn; Schneider, Jeffrey; Shansab, Maryam; Bastian, Arangassery Rosemary; Fahrbach, Kelly; Smith, Archer; Mahan, Alison; Karim, Marcus; Licht, Anna; Zvonar, Ivan; Tedesco, Jacquelynn; Anderson, Meegan; Chapel, Anais; Suscovich, Todd; Malaspina, David; Streeck, Hendrik; Walker, Bruce D.; Kim, Arthur; Lauer, Georg; Altfeld, Marcus; Pillai, Shiv; Szleifer, Igal; Kelleher, Neil L.; Kiser, Patrick F.; Hope, Thomas J.; Alter, Galit (2016)
      Transmission of HIV across mucosal barriers accounts for the majority of HIV infections worldwide. Thus, efforts aimed at enhancing protective immunity at these sites are a top priority, including increasing virus-specific ...

    • Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV Control 

      Ackerman, Margaret E.; Mikhailova, Anastassia; Brown, Eric P.; Dowell, Karen G.; Walker, Bruce D.; Bailey-Kellogg, Chris; Suscovich, Todd J.; Alter, Galit (Public Library of Science, 2016)
      Elite controllers (ECs) represent a unique model of a functional cure for HIV-1 infection as these individuals develop HIV-specific immunity able to persistently suppress viremia. Because accumulating evidence suggests ...

    • Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South Africa 

      Hölzemer, Angelique; Thobakgale, Christina F.; Jimenez Cruz, Camilo A.; Garcia-Beltran, Wilfredo F.; Carlson, Jonathan M.; van Teijlingen, Nienke H.; Mann, Jaclyn K.; Jaggernath, Manjeetha; Kang, Seung-gu; Körner, Christian; Chung, Amy W.; Schafer, Jamie L.; Evans, David T.; Alter, Galit; Walker, Bruce D.; Goulder, Philip J.; Carrington, Mary; Hartmann, Pia; Pertel, Thomas; Zhou, Ruhong; Ndung’u, Thumbi; Altfeld, Marcus (Public Library of Science, 2015)
      Background: Viruses can evade immune surveillance, but the underlying mechanisms are insufficiently understood. Here, we sought to understand the mechanisms by which natural killer (NK) cells recognize HIV-1-infected cells ...