Browsing Harvard Medical School by Author "LaFramboise, Thomas"

Now showing items 1-3 of 3

    • Allele-Specific Amplification in Cancer Revealed by SNP Array Analysis 

      LaFramboise, Thomas; Weir, Barbara Ann; Zhao, Xiaojun; Beroukhim, Rameen; Li, Cheng; Harrington, David Paul; Sellers, William R; Meyerson, Matthew Langer (Public Library of Science, 2005)
      Amplification, deletion, and loss of heterozygosity of genomic DNA are hallmarks of cancer. In recent years a variety of studies have emerged measuring total chromosomal copy number at increasingly high resolution. Similarly, ...

    • Allelic Selection of Amplicons in Glioblastoma Revealed by Combining Somatic and Germline Analysis 

      LaFramboise, Thomas; Dewal, Ninad; Wilkins, Katherine; Pe'er, Itsik; Freedman, Matthew Lawrence (Public Library of Science, 2010)
      Cancer is a disease driven by a combination of inherited risk alleles coupled with the acquisition of somatic mutations, including amplification and deletion of genomic DNA. Potential relationships between the inherited ...

    • Toward Accurate High-Throughput SNP Genotyping in the Presence of Inherited Copy Number Variation 

      MacConaill, Laura Eleanor; Aldred, Micheala A; Lu, Xincheng; LaFramboise, Thomas (BioMed Central, 2007)
      Background: The recent discovery of widespread copy number variation in humans has forced a shift away from the assumption of two copies per locus per cell throughout the autosomal genome. In particular, a SNP site can no ...