Browsing Harvard Medical School by Author "Babitt, Jodie"

Now showing items 1-6 of 6

    • Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasis 

      Core, Amanda B.; Canali, Susanna; Babitt, Jodie L. (Frontiers Media S.A., 2014)
      Mutations in hemojuvelin (HJV) are the most common cause of the juvenile-onset form of the iron overload disorder hereditary hemochromatosis. The discovery that HJV functions as a co-receptor for the bone morphogenetic ...

    • Hepcidin Regulation by BMP Signaling in Macrophages Is Lipopolysaccharide Dependent 

      Wu, Xinggang; Yung, Lai-Ming; Cheng, Wai-Hang; Yu, Paul B.; Babitt, Jodie L.; Lin, Herbert Yih-Fuu; Xia, Yin (Public Library of Science, 2012)
      Hepcidin is an antimicrobial peptide, which also negatively regulates iron in circulation by controlling iron absorption from dietary sources and iron release from macrophages. Hepcidin is synthesized mainly in the liver, ...

    • Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production 

      David, Valentin; Martin, Aline; Isakova, Tamara; Spaulding, Christina; Qi, Lixin; Ramirez, Veronica; Zumbrennen-Bullough, Kimberly B.; Sun, Chia Chi; Lin, Herbert Y.; Babitt, Jodie L.; Wolf, Myles (2015)
      Circulating levels of fibroblast growth factor 23 (FGF23) are elevated in patients with chronic kidney disease (CKD), but the mechanisms are poorly understood. Here we tested whether inflammation and iron deficiency regulate ...

    • Inflammation Regulates TMPRSS6 Expression via STAT5 

      Meynard, Delphine; Sun, Chia Chi; Wu, Qifang; Chen, Wenjie; Chen, Shanzhuo; Nelson, Caroline N.; Waters, Michael J.; Babitt, Jodie L.; Lin, Herbert Y. (Public Library of Science, 2013)
      TMPRSS6 is a regulated gene, with a crucial role in the regulation of iron homeostasis by inhibiting hepcidin expression. The main regulator of iron homeostasis, the antimicrobial peptide hepcidin, which also has a role ...

    • On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver 

      Theurl, Igor; Hilgendorf, Ingo; Nairz, Manfred; Tymoszuk, Piotr; Haschka, David; Asshoff, Malte; He, Shun; Gerhardt, Louisa M. S.; Holderried, Tobias A. W.; Seifert, Markus; Sopper, Sieghart; Fenn, Ashley M.; Anzai, Atsushi; Rattik, Sara; McAlpine, Cameron; Theurl, Milan; Wieghofer, Peter; Iwamoto, Yoshiko; Weber, Georg F.; Harder, Nina K.; Chousterman, Benjamin G.; Arvedson, Tara L.; McKee, Mary; Wang, Fudi; Lutz, Oliver M. D.; Rezoagli, Emanuele; Babitt, Jodie L.; Berra, Lorenzo; Prinz, Marco; Nahrendorf, Matthias; Weiss, Guenter; Weissleder, Ralph; Lin, Herbert Y.; Swirski, Filip K. (2016)
      Iron is an essential component of the erythrocyte protein hemoglobin and is crucial to oxygen transport in vertebrates. In the steady state, erythrocyte production is in equilibrium with erythrocyte removal1. In various ...

    • Repulsive Guidance Molecule (RGM) Family Proteins Exhibit Differential Binding Kinetics for Bone Morphogenetic Proteins (BMPs) 

      Wu, Qifang; Sun, Chia Chi; Lin, Herbert Yih-Fuu; Babitt, Jodie L. (Public Library of Science, 2012)
      Bone morphogenetic proteins (BMPs) are members of the transforming growth factor beta superfamily that exert their effects via type I and type II serine threonine kinase receptors and the SMAD intracellular signaling pathway ...