Browsing Harvard Medical School by Author "Janssen, Henk M."

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    • Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform 

      Gianella, Anita; Mieszawska, Aneta J.; Hoeben, Freek J. M.; Janssen, Henk M.; Jarzyna, Peter A.; Cormode, David P.; Costa, Kevin D.; Rao, Satish; Farokhzad, Omid Cameron; Langer, Robert S.; Fayad, Zahi A.; Mulder, Willem J. M. (Royal Society of Chemistry (RSC), 2013)
      We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and ...