Browsing Harvard Medical School by Author "Lifson, Jeffrey"

Now showing items 1-3 of 3

    • HLA-B*35-Px–mediated Acceleration of HIV-1 Infection by Increased Inhibitory Immunoregulatory Impulses 

      Goedert, James J.; Sundberg, Eric J.; Cung, Thai Duong Hong; Burke, Patrick S.; Preiss, Liliana; Lifson, Jeffrey; Carrington, Mary; Huang, Jinghe; Martin, Maureen P.; Lichterfeld, Mathias; Yu, Xu (The Rockefeller University Press, 2009)
      A subset of HLA-B*35 alleles, B*35-Px, are strongly associated with accelerated HIV-1 disease progression for reasons that are not understood. Interestingly, the alternative set of B*35 subtypes, B*35-PY, have no detectable ...

    • In Vitro Priming Recapitulates In Vivo HIV-1 Specific T Cell Responses, Revealing Rapid Loss of Virus Reactive CD4+ T Cells in Acute HIV-1 Infection 

      Lubong Sabado, Rachel; Kavanagh, Daniel Garrett; Kaufmann, Daniel; Fru, Karlhans; Babcock, Ethan; Rosenberg, Eric Scott; Walker, Bruce David; Lifson, Jeffrey; Bhardwaj, Nina; Larsson, Marie (Public Library of Science, 2009)
      Background: The requirements for priming of HIV-specific T cell responses initially seen in infected individuals remain to be defined. Activation of T cell responses in lymph nodes requires cell-cell contact between T cells ...

    • SIV Vpx Is Essential for Macrophage Infection but Not for Development of AIDS 

      Westmoreland, Susan V.; Converse, A. Peter; Hrecka, Kasia; Hurley, Mollie; Knight, Heather; Piatak, Michael; Lifson, Jeffrey; Mansfield, Keith G.; Skowronski, Jacek; Desrosiers, Ronald C. (Public Library of Science, 2014)
      Analysis of rhesus macaques infected with a vpx deletion mutant virus of simian immunodeficiency virus mac239 (SIVΔvpx) demonstrates that Vpx is essential for efficient monocyte/macrophage infection in vivo but is not ...