Browsing Harvard Medical School by Author "Borges, Thiago J."
Now showing items 1-4 of 4
-
Modulation of Alloimmunity by Heat Shock Proteins
Borges, Thiago J.; Lang, Benjamin J.; Lopes, Rafael L.; Bonorino, Cristina (Frontiers Media S.A., 2016)The immunological mechanisms that evolved for host defense against pathogens and injury are also responsible for transplant rejection. Host rejection of foreign tissue was originally thought to be mediated mainly by T cell ... -
The Scavenger Receptor SREC-I Cooperates with Toll-Like Receptors to Trigger Inflammatory Innate Immune Responses
Murshid, Ayesha; Borges, Thiago J.; Lang, Benjamin J.; Calderwood, Stuart K. (Frontiers Media S.A., 2016)Scavenger receptor expressed by endothelial cell-I (SREC-I) is a class F scavenger receptor expressed by immune cells with a significant role in CD8+- and CD4+-mediated T cell immunity. This receptor can also modulate the ... -
Scavenger Receptor SREC-I Mediated Entry of TLR4 into Lipid Microdomains and Triggered Inflammatory Cytokine Release in RAW 264.7 Cells upon LPS Activation
Murshid, Ayesha; Gong, Jianlin; Prince, Thomas; Borges, Thiago J.; Calderwood, Stuart K. (Public Library of Science, 2015)Scavenger receptor associated with endothelial cells I (SREC-I) was shown to be expressed in immune cells and to play a role in the endocytosis of peptides and antigen presentation. As our previous studies indicated that ... -
Severe acute interstitial nephritis after combination immune-checkpoint inhibitor therapy for metastatic melanoma
Murakami, Naoka; Borges, Thiago J.; Yamashita, Michifumi; Riella, Leonardo V. (Oxford University Press, 2016)Immune-checkpoint inhibitors are emerging as revolutionary drugs for certain malignancies. However, blocking the co-inhibitory signals may lead to immune-related adverse events, mainly in the spectrum of autoimmune diseases ...