Browsing Harvard Medical School by Title

Now showing items 14080-14099 of 18465

    • A Public Resource Facilitating Clinical Use of Genomes 

      Ball, Madeleine P.; Thakuria, Joseph V.; Zaranek, Alexander Wait; Clegg, Tom; Rosenbaum, Abraham M.; Wu, Xiaodi; Angrist, Misha; Bhak, Jong; Bobe, Jason R; Callow, Matthew J.; Cano, Carlos; Chou, Michael; Chung, Wendy K.; Douglas, Shawn M.; Estep, Preston W.; Gore, Athurva; Hulick, Peter; Labarga, Alberto; Lee, Je-Hyuk; Lunshof, Jeantine E.; Kim, Byung Chul; Kim, Jong-Il; Li, Zhe; Murray, Michael F; Nilsen, Geoffrey B.; Peters, Brock A.; Raman, Anugraha M.; Rienhoff, Hugh Y.; Robasky, Kimberly; Wheeler, Matthew T.; Vandewege, Ward; Vorhaus, Daniel B.; Yang, Joyce L.; Yang, Luhan; Aach, John; Ashley, Euan A.; Drmanac, Radoje; Kim, Seong-Jin; Li, Jin Billy; Peshkin, Leonid; Seidman, Christine; Seo, Jeong-Sun; Zhang, Kun; Rehm, Heidi; Church, George (National Academy of Sciences, 2012-07-24)
      Rapid advances in DNA sequencing promise to enable new diagnostics and individualized therapies. Achieving personalized medicine, however, will require extensive research on highly reidentifiable, integrated datasets of ...

    • Publication Trends in Acupuncture Research: A 20-Year Bibliometric Analysis Based on PubMed 

      Ma, Yan; Dong, Ming; Zhou, Kehua; Mita, Carol; Liu, Jianping; Wayne, Peter M. (Public Library of Science, 2016)
      Objective: Acupuncture has become popular and widely practiced in many countries around the world. Despite the large amount of acupuncture-related literature that has been published, broader trends in the prevalence and ...

    • Publish or perish: tools for survival 

      Quan, Stuart Fun; Borus, Jonathan Frederick (Southwest Journal of Pulmonary and Critical Care, 2017)
      Success in one’s chosen profession is often predicated upon meeting a profession-wide standard of excellence or productivity. In the corporate world, the metric might be sales volume and in clinical medicine it may be ...

    • PubMed search filters for the study of putative outdoor air pollution determinants of disease 

      Curti, Stefania; Gori, Davide; Di Gregori, Valentina; Farioli, Andrea; Baldasseroni, Alberto; Fantini, Maria Pia; Christiani, David C; Violante, Francesco S; Mattioli, Stefano (BMJ Publishing Group, 2016)
      Objectives: Several PubMed search filters have been developed in contexts other than environmental. We aimed at identifying efficient PubMed search filters for the study of environmental determinants of diseases related ...

    • PuF, An Antimetastatic and Developmental Signaling Protein, Interacts with the Alzheimer’s Amyloid-β Precursor Protein via a Tissue-Specific Proximal Regulatory Element (PRE) 

      Lahiri, Debomoy K; Maloney, Bryan; Rogers, Jack Timothy; Ge, Yuan-Wen (BioMed Central, 2013)
      Background: Alzheimer’s disease (AD) is intimately tied to amyloid-β (Aβ) peptide. Extraneuronal brain plaques consisting primarily of Aβ aggregates are a hallmark of AD. Intraneuronal Aβ subunits are strongly implicated ...

    • Pulmonary adenocarcinoma mutation profile in smokers with smoking-related interstitial fibrosis 

      Primiani, Andrea; Dias-Santagata, Dora; Iafrate, A John; Kradin, Richard L (Dove Medical Press, 2014)
      Cigarette smoking is an established cause of lung cancer. However, pulmonary fibrosis is also an independent risk factor for the development of lung cancer. Smoking-related interstitial fibrosis (SRIF) has recently been ...

    • Pulmonary embolism: the diagnosis, risk-stratification, treatment and disposition of emergency department patients 

      Corrigan, Daniel; Prucnal, Christiana; Kabrhel, Christopher (The Korean Society of Emergency Medicine, 2016)
      The diagnosis or exclusion of pulmonary embolism (PE) remains challenging for emergency physicians. Symptoms can be vague or non-existent, and the clinical presentation shares features with many other common diagnoses. ...

    • Pulmonary hypertension caused by pulmonary venous hypertension 

      Kulik, Thomas J. (University of Chicago Press, 2014)
      Abstract The effect of pulmonary venous hypertension (PVH) on the pulmonary circulation is extraordinarily variable, ranging from no impact on pulmonary vascular resistance (PVR) to a marked increase. The reasons for this ...

    • Pulmonary Oxygen Toxicity: Investigation and Mentoring 

      Hedley-Whyte, John (The Ulster Medical Society, 2008)
      SUMMARY At sea level oxygen is toxic to man when breathed for more than twenty-four hours at a percentage greater than about forty percent. Pulmonary pathology is the first manifestation in subjects with previously normal ...

    • Pulmonary Toxicity in Hamsters of Smoke Particles from Kuwaiti Oil Fires. 

      Brain, Joseph David; Long, N. C.; Wolfthal, S F; Dumyahn, T; Dockery, Douglas W. (National Institute of Environmental Health Sciences, 1998)
      The Kuwaiti oil wells set on fire by retreating Iraqi troops at the end of the Persian Gulf War released complex particles, inorganic and organic gases, and hydrocarbons into the atmosphere, damaging the environment where ...

    • Pulse Wave Analysis by Applanation Tonometry for the Measurement of Arterial Stiffness 

      Doupis, John; Papanas, Nikolaos; Cohen, Alison; McFarlan, Lyndsay; Horton, Edward (Bentham Open, 2016)
      The aim of our study was to investigate the association between pulse wave velocity (PWV) and pulse wave analysis (PWA)-derived measurements for the evaluation of arterial stiffness. A total of 20 (7 male and 13 female) ...

    • Pulseq‐CEST: Towards multi‐site multi‐vendor compatibility and reproducibility of CEST experiments using an open‐source sequence standard 

      Herz, Kai; Mueller, Sebastian; Perlman, Or; Zaitsev, Maxim; Knutsson, Linda; Sun, Phillip Zhe; Zhou, Jinyuan; van Zijl, Peter; Heinecke, Kerstin; Schuenke, Patrick; Farrar, Christian; Schmidt, Manuel; Dörfler, Arnd; Scheffler, Klaus; Zaiss, Moritz (Wiley, 2021-05-07)
      Purpose: As the field of CEST grows, various novel preparation periods using different parameters are being introduced. At the same time, large, multisite clinical studies require clearly defined protocols, especially ...

    • Purification and characterization of heparin-binding endothelial cell growth factors. 

      Lobb, Roy; Sasse, Joachim; Sullivan, Robert; Shing, Yuen; D'Amore, Patricia Ann; Jacobs, Jeffrey; Klagsbrun, Michael (American Society for Biochemistry and Molecular Biology, 1986)

    • Purification of germline stem cells from adult mammalian ovaries: a step closer towards control of the female biological clock? 

      Tilly, Jonathan Lee; Telfer, Evelyn E. (Oxford University Press, 2009)
      For decades it was believed that a non-renewable pool of oocyte-containing follicles is established in female mammals at birth. This cornerstone of reproductive biology was challenged 5 years ago by a study reporting on ...

    • Purification of α-Synuclein from Human Brain Reveals an Instability of Endogenous Multimers as the Protein Approaches Purity 

      Luth, Eric S.; Bartels, Tim; Dettmer, Ulf; Kim, Nora C.; Selkoe, Dennis J. (American Chemical Society, 2014)
      Despite two decades of research, the structure–function relationships of endogenous, physiological forms of α-synuclein (αSyn) are not well understood. Most in vitro studies of this Parkinson’s disease-related protein have ...

    • Purine and pyrimidine metabolism: Convergent evidence on chronic antidepressant treatment response in mice and humans 

      Park, Dong Ik; Dournes, Carine; Sillaber, Inge; Uhr, Manfred; Asara, John M.; Gassen, Nils C.; Rein, Theo; Ising, Marcus; Webhofer, Christian; Filiou, Michaela D.; Müller, Marianne B.; Turck, Christoph W. (Nature Publishing Group, 2016)
      Selective Serotonin Reuptake Inhibitors (SSRIs) are commonly used drugs for the treatment of psychiatric diseases including major depressive disorder (MDD). For unknown reasons a substantial number of patients do not show ...

    • Purinergic P2Y12 Receptor Activation in Eosinophils and the Schistosomal Host Response 

      Muniz, Valdirene S.; Baptista-dos-Reis, Renata; Benjamim, Claudia F.; Mata-Santos, Hilton A.; Pyrrho, Alexandre S.; Strauch, Marcelo A.; Melo, Paulo A.; Vicentino, Amanda R. R.; Silva-Paiva, Juliana; Bandeira-Melo, Christianne; Weller, Peter F.; Figueiredo, Rodrigo T.; Neves, Josiane S. (Public Library of Science, 2015)
      Identifying new target molecules through which eosinophils secrete their stored proteins may reveal new therapeutic approaches for the control of eosinophilic disorders such as host immune responses to parasites. We have ...

    • The purinergic P2Y14 receptor axis is a molecular determinant for organism survival under in utero radiation toxicity 

      Kook, S H; Cho, J S; Morrison, A; Wiener, E; Lee, S B; Scadden, D; Lee, B-C (Nature Publishing Group, 2013)
      In utero exposure of the embryo and fetus to radiation has been implicated in malformations or fetal death, and often produces lifelong health consequences such as cancers and mental retardation. Here we demonstrate that ...

    • Purinergic Signaling as a Regulator of Th17 Cell Plasticity 

      Fernández, Dominique; Flores-Santibáñez, Felipe; Neira, Jocelyn; Osorio-Barrios, Francisco; Tejón, Gabriela; Nuñez, Sarah; Hidalgo, Yessia; Fuenzalida, Maria Jose; Meza, Daniel; Ureta, Gonzalo; Lladser, Alvaro; Pacheco, Rodrigo; Acuña-Castillo, Claudio; Guixé, Victoria; Quintana, Francisco J.; Bono, Maria Rosa; Rosemblatt, Mario; Sauma, Daniela (Public Library of Science, 2016)
      T helper type 17 (Th17) lymphocytes, characterized by the production of interleukin-17 and other pro-inflammatory cytokines, are present in intestinal lamina propria and have been described as important players driving ...

    • Puromycin-sensitive Aminopeptidase Protects Against Aggregation-prone Proteins via Autophagy 

      Menzies, Fiona M.; Hourez, Raphael; Imarisio, Sara; Raspe, Marcel; Sadiq, Oana; Chandraratna, Dhia; O'Kane, Cahir; Rock, Kenneth L.; Reits, Eric; Rubinsztein, David C.; Goldberg, Alfred L. (Oxford University Press, 2010)
      A major function of proteasomes and macroautophagy is to eliminate misfolded potentially toxic proteins. Mammalian proteasomes, however, cannot cleave polyglutamine (polyQ) sequences and seem to release polyQ-rich peptides. ...