Browsing Harvard Medical School by Title
Now showing items 4464-4483 of 18448
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Differential role of nonhomologous end joining factors in the generation, DNA damage response, and myeloid differentiation of human induced pluripotent stem cells
(National Academy of Sciences, 2014)Nonhomologous end-joining (NHEJ) is a key pathway for efficient repair of DNA double-strand breaks (DSBs) and V(D)J recombination. NHEJ defects in humans cause immunodeficiency and increased cellular sensitivity to ionizing ... -
Differential Roles of Direct and Indirect Allorecognition Pathways in the Rejection of Skin and Corneal Transplants
(Ovid Technologies (Wolters Kluwer Health), 2009)Background It is generally accepted that all transplants are not rejected in the same fashion. However, the extrinsic and intrinsic factors that control the recognition and rejection of a particular allograft by the ... -
Differential roles of microglia and monocytes in the inflamed central nervous system
(The Rockefeller University Press, 2014)In the human disorder multiple sclerosis (MS) and in the model experimental autoimmune encephalomyelitis (EAE), macrophages predominate in demyelinated areas and their numbers correlate to tissue damage. Macrophages may ... -
Differential Roles of the Pseudomonas aeruginosa PA14 rpoN Gene in Pathogenicity in Plants, Nematodes, Insects, and Mice
(American Society for Microbiology, 2001)We cloned the rpoN (ntrA, glnF) gene encoding the alternate sigma factor sigma (54) from the opportunistic multihost pathogen Pseudomonas aeruginosa strain PA14. A marker exchange protocol was used to construct the PA14 ... -
Differential Sensitivities of Retroviruses to Integrase Strand Transfer Inhibitors
(American Society for Microbiology, 2011)Integrase inhibitors are emerging anti-human immunodeficiency virus (HIV) drugs, and multiple retroviruses and transposable elements were evaluated here for susceptibilities to raltegravir (RAL) and elvitegravir (EVG). All ... -
Differential Sensitivity of Melanoma Cell Lines with BRAFV600E Mutation to the Specific Raf Inhibitor PLX4032
(BioMed Central, 2010)Blocking oncogenic signaling induced by the BRAFV600E mutation is a promising approach for melanoma treatment. We tested the anti-tumor effects of a specific inhibitor of Raf protein kinases, PLX4032/RG7204, in melanoma ... -
Differential Stem and Progenitor Cell Trafficking by Prostaglandin E2
(2013)SUMMARY To maintain lifelong production of blood cells, hematopoietic stem cells (HSC) are tightly regulated by inherent programs and extrinsic regulatory signals received from their microenvironmental niche. Long-term ... -
Differential strand separation at critical temperature: A minimally disruptive enrichment method for low-abundance unknown DNA mutations
(Oxford University Press, 2012)Detection of low-level DNA variations in the presence of wild-type DNA is important in several fields of medicine, including cancer, prenatal diagnosis and infectious diseases. PCR-based methods to enrich mutations during ... -
Differential Time Trends of Outcomes and Costs of Care for Acute Myocardial Infarction Hospitalizations by ST Elevation and Type of Intervention in the United States, 2001–2011
(Blackwell Publishing Ltd, 2015)Background: Little is known whether time trends of in‐hospital mortality and costs of care for acute myocardial infarction (AMI) differ by type of AMI (ST‐elevation myocardial infarction [STEMI] vs. non‐ST‐elevation [NSTEMI]) ... -
Differential, Phosphorylation Dependent Trafficking of AQP2 in LLC-PK1 Cells
(Public Library of Science, 2012)The kidney maintains water homeostasis by modulating aquaporin 2 (AQP2) on the plasma membrane of collecting duct principal cells in response to vasopressin (VP). VP mediated phosphorylation of AQP2 at serine 256 is critical ... -
Differentially Charged Hollow Core/Shell Lipid-Polymer-Lipid Hybrid Nanoparticles for Small Interfering RNA Delivery
(Wiley-Blackwell, 2011)Speedy delivery: Biodegradable and biocompatible polymers and lipids form hybrid core/shell nanoparticles (see picture, left) that show promising in vitro and in vivo results for delivering siRNA. The unique lipid–polymer–lipid ... -
Differentially Expressed Alternatively Spliced Genes in Malignant Pleural Mesothelioma Identified Using Massively Parallel Transcriptome Sequencing
(BioMed Central, 2009)Background: Analyses of Expressed Sequence Tags (ESTs) databases suggest that most human genes have multiple alternative splice variants. The alternative splicing of pre-mRNA is tightly regulated during development and in ... -
Differentiating Branch Duct and Mixed IPMN in Endoscopically Collected Pancreatic Cyst Fluid via Cytokine Analysis
(Hindawi Publishing Corporation, 2012)Background: Differentiating branch duct from mixed intraductal papillary mucinous neoplasm (BD-IPMN) is problematic, but clinically important as mixed IPMNs are managed surgically, while some BD-IPMN may be followed. ... -
Differentiating Cognitive Impairment from Symptoms of Anxiety in Postcoronary Artery Bypass Grafting Encephalopathy: A Case Report
(Dove Medical Press, 2006)Post-coronary artery bypass grafting encephalopathy (CABGE) is associated with cognitive decline in a significant number of post-cardiac surgery cases. Patients may experience this condition as a result of being maintained ... -
Differentiating Maturational and Training Influences on fMRI Activation During Music Processing
(Elsevier BV, 2012-04-15)Two major influences on how the brain processes music are maturational development and active musical training. Previous functional neuroimaging studies investigating music processing have typically focused on either ... -
Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity
(eLife Sciences Publications, Ltd, 2016)Mesenchymal stem cell (MSC) differentiation is mediated by soluble and physical cues. In this study, we investigated differentiation-induced transformations in MSC cellular and nuclear biophysical properties and queried ... -
The Differentiation and Stress Response Factor XBP-1 Drives Multiple Myeloma Pathogenesis
(Cell Press, 2007)Multiple myeloma (MM) evolves from a highly prevalent premalignant condition termed MGUS. The factors underlying the malignant transformation of MGUS are unknown. We report a MGUS/MM phenotype in transgenic mice with ... -
Differentiation of neurons from neural precursors generated in floating spheres from embryonic stem cells
(BioMed Central, 2009)Background: Neural differentiation of embryonic stem (ES) cells is usually achieved by induction of ectoderm in embryoid bodies followed by the enrichment of neuronal progenitors using a variety of factors. Obtaining ... -
Differentiation-Specific Histone Modifications Reveal Dynamic Chromatin Interactions and Partners for the Intestinal Transcription Factor CDX2
(Elsevier BV, 2010)Cell differentiation requires remodeling of tissue-specific gene loci and activities of key transcriptional regulators, which are recognized for their dominant control over cellular programs. Using epigenomic methods, we ... -
Diffractionless beam in free space with adiabatic changing refractive index in a single mode tapered slab waveguide
(Optical Society of America, 2009)