Browsing Harvard Medical School by Title
Now showing items 4596-4615 of 18465
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Discovery of Progenitor Cell Signatures by Time-Series Synexpression Analysis During Drosophila Embryonic Cell Immortalization
(National Academy of Sciences, 2015-10-20)The use of time series profiling to identify groups of functionally related genes (synexpression groups) is a powerful approach for the discovery of gene function. Here we apply this strategy during RasV12 immortalization ... -
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
(Springer Science and Business Media LLC, 2020-11-23)Genetic studies of blood pressure (BP) to date have mainly analysed common variants (minor allele frequency, MAF>0.05). In a meta-analysis of up to >1.3 million participants, we discovered 106 new BP-associated genomic ... -
Discovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2)
(American Chemical Society, 2014)We developed a pharmacophore model for type II inhibitors that was used to guide the construction of a library of kinase inhibitors. Kinome-wide selectivity profiling of the library resulted in the identification of a ... -
The Discrepancy between Patient and Clinician Reported Function in Extremity Bone Metastases
(Hindawi Publishing Corporation, 2016)Background:. The Musculoskeletal Tumor Society (MSTS) scoring system measures function and is commonly used but criticized because it was developed to be completed by the clinician and not by the patient. We therefore ... -
Discrepancy in patient-rated and oncologist-rated performance status on depression and anxiety in cancer: a prospective study protocol
(BMJ Group, 2012)Objective: Psychological distress is common in patients with cancer. We need a rapid means of screening for and identifying depression and anxiety in patients with cancer. The present study evaluates the potential of the ... -
Discrete Logic Modelling as a Means to Link Protein Signalling Networks with Functional Analysis of Mammalian Signal Transduction
(Nature Publishing Group, 2009)Large-scale protein signalling networks are useful for exploring complex biochemical pathways but do not reveal how pathways respond to specific stimuli. Such specificity is critical for understanding disease and designing ... -
Discrete States of a Protein Interaction Network Govern Interphase and Mitotic Microtubule Dynamics
(Public Library of Science, 2007)The cytoplasm of eukaryotic cells is thought to adopt discrete “states” corresponding to different steady states of protein networks that govern changes in subcellular organization. For example, in Xenopus eggs, the ... -
Discriminant and Concurrent Validity of a Simplified DSM-Based Structured Diagnostic Instrument for the Assessment of Autism Spectrum Disorders in Youth and Young Adults
(BioMed Central, 2011)Background: To evaluate the concurrent and discriminant validity of a brief DSM-based structured diagnostic interview for referred individuals with autism spectrum disorders (ASDs). Methods: To test concurrent validity, ... -
Discriminating Grotesque from Typical Faces: Evidence from the Thatcher Illusion
(Public Library of Science, 2011)The discrimination of thatcherized faces from typical faces was explored in two simultaneous alternative forced choice tasks. Reaction times (RTs) and errors were measured in a behavioural task. Brain activation was measured ... -
Disease Ecology, Biodiversity, and the Latitudinal Gradient in Income
(Public Library of Science, 2012)While most of the world is thought to be on long-term economic growth paths, more than one-sixth of the world is roughly as poor today as their ancestors were hundreds of years ago. The majority of the extremely poor live ... -
A DIseAse MOdule Detection (DIAMOnD) Algorithm Derived from a Systematic Analysis of Connectivity Patterns of Disease Proteins in the Human Interactome
(Public Library of Science, 2015)The observation that disease associated proteins often interact with each other has fueled the development of network-based approaches to elucidate the molecular mechanisms of human disease. Such approaches build on the ... -
Disease Surveillance on Complex Social Networks
(Public Library of Science, 2016)As infectious disease surveillance systems expand to include digital, crowd-sourced, and social network data, public health agencies are gaining unprecedented access to high-resolution data and have an opportunity to ... -
Disease variant prediction with deep generative models of evolutionary data
(Springer Science and Business Media LLC, 2021-10-27) -
Disease-Associated Mutations Prevent GPR56-Collagen III Interaction
(Public Library of Science, 2012)GPR56 is a member of the adhesion G protein-coupled receptor (GPCR) family. Mutations in GPR56 cause a devastating human brain malformation called bilateral frontoparietal polymicrogyria (BFPP). Using the N-terminal fragment ... -
DiseaseConnect: a comprehensive web server for mechanism-based disease–disease connections
(Oxford University Press, 2014)The DiseaseConnect (http://disease-connect.org) is a web server for analysis and visualization of a comprehensive knowledge on mechanism-based disease connectivity. The traditional disease classification system groups ... -
Disentangling linear and nonlinear brain responses to evoked deep tissue pain
(Ovid Technologies (Wolters Kluwer Health), 2012)Pain stimuli evoke widespread responses in the brain. However, our understanding of the physiological significance underlying heterogeneous response within different pain-activated and -deactivated regions is still limited. ... -
Disinhibition in Risky Sexual Behavior in Men, but Not Women, during Four Years of Antiretroviral Therapy in Rural, Southwestern Uganda
(Public Library of Science, 2013)Background: In resource-rich areas, risky sexual behavior (RSB) largely diminishes after initiation of anti-retroviral therapy, with notable exceptions among some populations who perceive a protected benefit from anti-retroviral ... -
Dismantling Limb-Girdle Muscular Dystrophy
(American Medical Association (AMA), 2015)Muscular dystrophy encompasses a diverse group of genetically determined muscle disorders. The first clinical description of the disorder is attributed to Giovanni Semmola, who, in 1829, described 2 boys affected by a ... -
Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1α/ERRγ complex
(National Academy of Sciences, 2011)