Browsing Harvard Medical School by Title

Now showing items 3708-3727 of 18441

    • Craniectomy for Malignant Cerebral Infarction: Prevalence and Outcomes in US Hospitals 

      Walcott, Brian; Kuklina, Elena V.; Nahed, Brian Vala; George, Mary G.; Kahle, Kristopher; Simard, J. Marc; Asaad, Wael F.; Coumans, Jean-Valery C E (Public Library of Science (PLoS), 2011)
      Object: Randomized trials have demonstrated the efficacy of craniectomy for the treatment of malignant cerebral edema following ischemic stroke. We sought to determine the prevalence and outcomes related to this by using ...

    • Cranio-Spinal Migration of a Metallic Clip Placed During Arteriovenous Malformation Resection - A Case Report, Review of the Literature, and Management Strategies 

      Chen, Clark Chin-Chung; Zinn, Pascal Olivier; Kasper, Ekkehard Matthias; Ogilvy, Christopher S. (BioMed Central, 2010)
      Background: Microclip placement during AVM resection is generally accepted to be a safe practice in neurosurgery. Here, we describe an unusual complication involving cranio-spinal clip migration discovered five years after ...

    • Craniofacial features as assessed by lateral cephalometric measurements in children with Down syndrome 

      Allareddy, Veerasathpurush; Ching, Nicholas; Macklin, Eric A.; Voelz, Lauren; Weintraub, Gil; Davidson, Emily; Prock, Lisa Albers; Rosen, Dennis; Brunn, Richard; Skotko, Brian G. (Springer Berlin Heidelberg, 2016)
      Objective: The objective of the present study is to examine the craniofacial development of patients with Down syndrome (DS) and compare them with a neurotypical population. Methods: This study is a cross-sectional analysis ...

    • Craniofacial Measurements of Donors and Recipients Correlate with Aesthetic Outcome in Virtual Face Transplantation 

      S. Wallins, Joseph; Chandawarkar, Akash A.; Dobry, Allison; Diaz-Siso, J. Rodrigo; Bueno, Ericka M.; Caterson, Edward J.; Jania, Camille; Hevelone, Nathanael D.; Lipsitz, Stuart R.; Mukundan, Srinivasan; Pomahac, Bohdan (Wolters Kluwer Health, 2015)
      Background: Face transplantation is an increasingly feasible option for patients with severe disfigurement. Donors and recipients are currently matched based on immune compatibility, skin characteristics, age, and gender. ...

    • Cream Formulation Impact on Topical Administration of Engineered Colloidal Nanoparticles 

      Santini, Benedetta; Zanoni, Ivan; Marzi, Roberta; Cigni, Clara; Bedoni, Marzia; Gramatica, Furio; Palugan, Luca; Corsi, Fabio; Granucci, Francesca; Colombo, Miriam (Public Library of Science, 2015)
      In order to minimize the impact of systemic toxicity of drugs in the treatment of local acute and chronic inflammatory reactions, the achievement of reliable and efficient delivery of therapeutics in/through the skin is ...

    • Creating a Pilot Educational Psychiatry Website: Opportunities, Barriers, and Next Steps 

      Torous, John; O'Connor, Ryan; Franzen, Jamie; Snow, Caitlin; Boland, Robert; Kitts, Robert (JMIR Publications Inc., 2015)
      Background: While medical students and residents may be utilizing websites as online learning resources, medical trainees and educators now have the opportunity to create such educational websites and digital tools on their ...

    • Creating and Analyzing Pathway and Protein Interaction Compendia for Modelling Signal Transduction Networks 

      Kirouac, Daniel C; Saez-Rodriguez, Julio; Swantek, Jennifer; Burke, John M; Lauffenburger, Douglas A; Sorger, Peter Karl (BioMed Central, 2012)
      Background: Understanding the information-processing capabilities of signal transduction networks, how those networks are disrupted in disease, and rationally designing therapies to manipulate diseased states require ...

    • Creating boundaries to empower digital health technology 

      Hsin, Honor; Torous, John (Royal College of Psychiatrists, 2018-07)
      The potential of digital health tools such as smartphones and sensors to increase access to and enhance delivery of healthcare is well known. However, a lack of regulation and delineation between those technologies seeking ...

    • Creating Critical Consumers of Health and Science News: Teaching Science to the Non-Scientist Using Newsworthy Topics in the Life Sciences† 

      Coderre, Raymond W.; Uekermann, Kristen A.; Choi, Youngeun; Anderson, William J. (American Society of Microbiology, 2016)
      Scientists constantly make groundbreaking discoveries, some of which receive attention from the press. We designed a course intended for a lay audience that provides the scientific background to appreciate these reports ...

    • Creation and implementation of SAMPRO™: A school-based asthma management program 

      Lemanske, Robert F.; Kakumanu, Sujani; Shanovich, Kathleen; Antos, Nicholas; Cloutier, Michelle M.; Mazyck, Donna; Phipatanakul, Wanda; Schantz, Shirley; Szefler, Stanley; Vandlik, Renee; Williams, Paul (2016)
      Clinicians who care for children with asthma have an obligation to coordinate asthma care with the schools. Aside from routine clinical care of asthmatic children, providers must educate the family and child about the need ...

    • Creation of an Open-Access, Mutation-Defined Fibroblast Resource for Neurological Disease Research 

      Wray, Selina; Self, Matthew; Lewis, Patrick A.; Taanman, Jan-Willem; Ryan, Natalie S.; Mahoney, Colin J.; Liang, Yuying; Devine, Michael J.; Sheerin, Una-Marie; Houlden, Henry; Morris, Huw R.; Healy, Daniel; Marti-Masso, Jose-Felix; Preza, Elisavet; Barker, Suzanne; Sutherland, Margaret; Corriveau, Roderick A.; D'Andrea, Michael; Schapira, Anthony H. V.; Uitti, Ryan J.; Guttman, Mark; Opala, Grzegorz; Jasinska-Myga, Barbara; Puschmann, Andreas; Nilsson, Christer; Espay, Alberto J.; Slawek, Jaroslaw; Gutmann, Ludwig; Boeve, Bradley F.; Boylan, Kevin; Stoessl, A. Jon; Ross, Owen A.; Maragakis, Nicholas J.; Van Gerpen, Jay; Gerstenhaber, Melissa; Gwinn, Katrina; Dawson, Ted M.; Marder, Karen S.; Clark, Lorraine N.; Przedborski, Serge E.; Finkbeiner, Steven; Rothstein, Jeffrey D.; Wszolek, Zbigniew K.; Rossor, Martin N.; Hardy, John; Isacson, Ole Stefan (Public Library of Science, 2012)
      Our understanding of the molecular mechanisms of many neurological disorders has been greatly enhanced by the discovery of mutations in genes linked to familial forms of these diseases. These have facilitated the generation ...

    • The crisis of patient-physician trust and bioethics: lessons and inspirations from China 

      Nie, Jing-Bao; Li, Lun; Gillett, Grant; Tucker, Joseph D.; Kleinman, Arthur Michael (Wiley-Blackwell, 2017)
      Trust is indispensable not only for interpersonal relationships and social life, but for good quality healthcare. As manifested in the increasing violence and tension in patient-physician relationships, China has been ...

    • CRISPR Display: A modular method for locus-specific targeting of long noncoding RNAs and synthetic RNA devices in vivo 

      Shechner, David M.; Hacisüleyman, Ezgi; Younger, Scott T.; Rinn, John L. (2016)
      Noncoding RNAs (ncRNAs) comprise an important class of regulatory molecules that mediate a vast array of biological processes. This broad functional capacity has also facilitated the design of artificial ncRNAs with novel ...

    • CRISPR DNA Base Editors With Reduced RNA Off-Target and Self-Editing Activities 

      Grünewald, Julian; Zhou, Ronghao; Iyer, Sowmya; Lareau, Caleb; Garcia, Sara; Aryee, Martin; Joung, Keith (Springer Science and Business Media LLC, 2019-09)
      Cytosine or adenine base editors (CBEs or ABEs) can introduce specific DNA C-to-T or A-to-G alterations1,2,3,4. However, we recently demonstrated that they can also induce transcriptome-wide guide-RNA-independent editing ...

    • CRISPR Guide RNA Design for Research Applications 

      Mohr, Stephanie; Hu, Yanhui; Ewen-Campen, Benjamin; Housden, Benjamin; Viswanatha, Raghuvir; Perrimon, Norbert (Wiley-Blackwell, 2016-09)
      The rapid rise of CRISPR as a technology for genome engineering and related research applications has created a need for algorithms and associated online tools that facilitate design of on‐target and effective guide RNAs ...

    • CRISPR RNA-guided activation of endogenous human genes 

      Maeder, Morgan L; Linder, Samantha J; Cascio, Vincent M; Fu, Yanfang; Ho, Quan H; Joung, J Keith (2013)
      Catalytically inactive CRISPR-associated 9 nuclease (dCas9) can be directed by short guide RNAs (gRNAs) to repress endogenous genes in bacteria and human cells. Here we show that a dCas9-VP64 transcriptional activation ...

    • CRISPR-Cas-amplified urinary biomarkers for multiplexed and portable cancer diagnostics 

      Hao, Liangliang; Zhao, Renee T.; Welch, Nicole; Tan, Edward Kah Wei; Zhong, Qian; Harzallah, Nour Saida; Ngambenjawong, Chayanon; Ko, Henry; Fleming, Heather E.; Sabeti, Pardis C.; Bhatia, Sangeeta N. (Springer Science and Business Media LLC, 2023-04-24)
      Synthetic biomarkers, exogenous probes that generate molecular reporters, represent an emerging paradigm in precision diagnostics with applications across infectious and noncommunicable diseases. These methods use multiplexing ...

    • CRISPR-Cas: To Take Up DNA or Not—That Is the Question 

      Weinberger, Ariel D; Gilmore, Michael S. (Elsevier BV, 2012)
      Historically landmark experiments showed that capsule switching is critical for Streptococcus pneumonia survival. Further studies demonstrated that capsule ‘transformation’ occurs via DNA uptake. In this issue of Cell Host ...

    • CRISPR-mediated direct mutation of cancer genes in the mouse liver 

      Xue, Wen; Chen, Sidi; Yin, Hao; Tammela, Tuomas; Papagiannakopoulos, Thales; Joshi, Nikhil S.; Cai, Wenxin; Yang, Gillian; Bronson, Roderick; Crowley, Denise G.; Zhang, Feng; Anderson, Daniel G.; Sharp, Phillip A.; Jacks, Tyler (2014)
      The study of cancer genes in mouse models has traditionally relied on genetically-engineered strains made via transgenesis or gene targeting in embryonic stem (ES) cells1. Here we describe a new method of cancer model ...

    • CRISPR/Cas9-Mediated Gene Knock-Down in Post-Mitotic Neurons 

      Straub, Christoph; Granger, Adam J.; Saulnier, Jessica L.; Sabatini, Bernardo L. (Public Library of Science, 2014)
      The prokaryotic adaptive immune system CRISPR/Cas9 has recently been adapted for genome editing in eukaryotic cells. This technique allows for sequence-specific induction of double-strand breaks in genomic DNA of individual ...