Browsing Harvard Medical School by Title
Now showing items 4424-4443 of 18440
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Differential attachment responses of male and female infants to frightening maternal behavior: Tend or befriend versus fight or flight?
(Wiley, 2005)Taylor and colleagues (2000) proposed that males tend to display fight or flight responses to threat while females are more likely to display affiliative “tend or befriend” responses. In light of this hypothesis, gender ... -
Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits
(BioMed Central, 2014)Background: The trimeric envelope glycoproteins (Env) on the surface of HIV-1 virions are the targets for neutralizing antibodies (NAbs). No candidate HIV-1 immunogen has yet induced potent, broadly active NAbs (bNAbs). ... -
Differential cerebral response to somatosensory stimulation of an acupuncture point vs. two non-acupuncture points measured with EEG and fMRI
(Frontiers Media SA, 2015)Acupuncture can be regarded as a complex somatosensory stimulation. Here, we evaluate whether the point locations chosen for a somatosensory stimulation with acupuncture needles differently change the brain activity in ... -
Differential Chemokine Gene Expression in Corneal Transplant Rejection
(Association for Research in Vision and Ophthalmology, 2018-01-23)purpose. To evaluate the differential gene expression of chemokines after corneal transplantation and to determine the chemokines associated with allograft rejection. methods. Orthotopic mouse corneal transplantation ... -
Differential Contribution of Monocytes to Heart Macrophages in Steady-State and after Myocardial Infarction
(American Heart Association, 2014)Rationale: Macrophages populate the steady-state myocardium. Previously, all macrophages were thought to arise from monocytes; however, it emerged that, in several organs, tissue-resident macrophages may self-maintain ... -
Differential Disruption of EWS-FLI1 Binding by DNA-Binding Agents
(Public Library of Science, 2013)Fusion of the EWS gene to FLI1 produces a fusion oncoprotein that drives an aberrant gene expression program responsible for the development of Ewing sarcoma. We used a homogenous proximity assay to screen for compounds ... -
Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity
(Elsevier, 2014)Objective: Lipoprotein lipase (LPL) is a key regulator of circulating triglyceride rich lipoprotein hydrolysis. In brain LPL regulates appetite and energy expenditure. Angiopoietin-like 4 (Angptl4) is a secreted protein ... -
Differential Effects of Bactericidal/Permeability-Increasing Protein (BPI) Analogues on Retinal Neovascularization and Retinal Pericyte Growth
(Association for Research in Vision and Ophthalmology, 2002)Purpose. Bactericidal/permeability-increasing protein (BPI), an antibacterial and lipopolysaccharide-neutralizing protein, also has an antiangiogenic effect. To evaluate the therapeutic role of BPI in ischemic retinopathies, ... -
Differential Effects of Human Immunodeficiency Virus Type 1 Capsid and Cellular Factors Nucleoporin 153 and LEDGF/p75 on the Efficiency and Specificity of Viral DNA Integration
(American Society for Microbiology, 2013)Retroviruses integrate into cellular DNA nonrandomly. Lentiviruses such as human immunodeficiency virus type 1 (HIV-1) favor the bodies of active genes and gene-enriched transcriptionally active regions of chromosomes. The ... -
Differential effects of human interleukin-1 on growth of human fibroblasts and vascular smooth muscle cells
(Ovid Technologies (Wolters Kluwer Health), 1985)Monocyte products probably play a role in the initiation of smooth muscle cell proliferation in the arterial wall early in atherogenesis. Several groups have described mitogenic activity for arterial smooth muscle cells ... -
Differential Effects of Isoxazole-9 on Neural Stem/Progenitor Cells, Oligodendrocyte Precursor Cells, and Endothelial Progenitor Cells
(Public Library of Science, 2015)Adult mammalian brain can be plastic after injury and disease. Therefore, boosting endogenous repair mechanisms would be a useful therapeutic approach for neurological disorders. Isoxazole-9 (Isx-9) has been reported to ... -
Differential effects of motor cortical excitability and plasticity in young and old individuals: a Transcranial Magnetic Stimulation (TMS) study
(Frontiers Media S.A., 2014)Aging is associated with changes in the motor system that, over time, can lead to functional impairments and contribute negatively to the ability to recover after brain damage. Unfortunately, there are still many questions ... -
Differential Effects of Sorafenib on Liver Versus Tumor Fibrosis Mediated by Stromal-Derived Factor 1 alpha/C-X-C Receptor Type 4 Axis and Myeloid Differentiation Antigen-Positive Myeloid Cell Infiltration in Mice
(Wiley-Blackwell, 2014)Sorafenib—a broad kinase inhibitor—is a standard therapy for advanced hepatocellular carcinoma (HCC) and has been shown to exert antifibrotic effects in liver cirrhosis, a precursor of HCC. However, the effects of sorafenib ... -
Differential Expression of Collagen Type V and XI ?-1 in Human Ascending Thoracic Aortic Aneurysms
(Elsevier BV, 2009)Background The molecular mechanisms leading to ascending thoracic aortic aneurysms (ATAAs) remain unknown. We hypothesized that alterations in expression levels of specific fibrillar collagens occur during the aneurysmal ... -
Differential Expression of Exosomal microRNAs in Prefrontal Cortices of Schizophrenia and Bipolar Disorder Patients
(Public Library of Science, 2013)Exosomes are cellular secretory vesicles containing microRNAs (miRNAs). Once secreted, exosomes are able to attach to recipient cells and release miRNAs potentially modulating the function of the recipient cell. We ... -
Differential expression of neurogenes among breast cancer subtypes identifies high risk patients
(Impact Journals LLC, 2016)The nervous system is now recognized to be a relevant component of the tumor microenvironment. Receptors for neuropeptides and neurotransmitters have been identified in breast cancer. However, very little is known about ... -
Differential Expression of Proteomics Models of Colorectal Cancer, Colorectal Benign Disease and Healthy Controls
(BioMed Central, 2010)Background: Colorectal cancer (CRC) is often diagnosed at a late stage with concomitant poor prognosis. The hypersensitive analytical technique of proteomics can detect molecular changes before the tumor is palpable. The ... -
Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells
(American Society for Clinical Investigation, 1999)Activated T lymphocytes accumulate early in atheroma formation and persist at sites of lesion growth and rupture, suggesting that they may play an important role in the pathogenesis of atherosclerosis. Moreover, atherosclerotic ... -
Differential Gene Expression between Sensory Neocortical Areas: Potential Roles for Ten_m3 and Bcl6 in Patterning Visual and Somatosensory Pathways
(Oxford University Press (OUP), 2007)Adult neocortical areas are characterized by marked differences in cytoarchitecture and connectivity that underlie their functional roles. The molecular determinants of these differences are largely unknown. We performed ... -
Differential Gene Expression in the Developing Lateral Geniculate Nucleus and Medial Geniculate Nucleus Reveals Novel Roles for Zic4 and Foxp2 in Visual and Auditory Pathway Development
(Society for Neuroscience, 2009)Primary sensory nuclei of the thalamus process and relay parallel channels of sensory input into the cortex. The developmental processes by which these nuclei acquire distinct functional roles are not well understood. To ...