Browsing Harvard Medical School by Title
Now showing items 6524-6543 of 18442
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A Flexibly Shaped Space-time Scan Statistic for Disease Outbreak Detection and Monitoring
(BioMed Central, 2008)Background: Early detection of disease outbreaks enables public health officials to implement disease control and prevention measures at the earliest possible time. A time periodic geographical disease surveillance system ... -
FLEXIQinase, a mass spectrometry-based assay, to unveil multi-kinase mechanisms
(2013)We introduce a mass spectrometry-based method that provides residue-resolved quantitative information about protein phosphorylation. In this FLEXIQinase assay we combined our Full-Length Expressed Stable Isotope-labeled ... -
Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity
(Rockefeller University Press, 2008)Caspase-1 and caspase-11 are proinflammatory caspases that regulate cytokine production and leukocyte migration during pathogen infection. In an attempt to identify new intracellular regulators of caspase-11, we found that ... -
Flip-Flop HSV-BAC: Bacterial Artificial Chromosome Based System for Rapid Generation of Recombinant Herpes Simplex Virus Vectors Using Two Independent Site-specific Recombinases
(BioMed Central, 2006)Background: Oncolytic herpes simplex virus (HSV) vectors that specifically replicate in and kill tumor cells sparing normal cells are a promising cancer therapy. Traditionally, recombinant HSV vectors have been generated ... -
Flipped Classroom in a Collectivistic Society: Reactions & Suggestions
(2016-06-07)Flipped classroom is an educational format that has been proven to provide many benefits. However, the format requires outspokenness and thus may not be congruent with collectivistic cultures. The present study was conducted ... -
Florbetaben PET in the Early Diagnosis of Alzheimer's Disease: A Discrete Event Simulation to Explore Its Potential Value and Key Data Gaps
(Hindawi Publishing Corporation, 2012)The growing understanding of the use of biomarkers in Alzheimer's disease (AD) may enable physicians to make more accurate and timely diagnoses. Florbetaben, a beta-amyloid tracer used with positron emission tomography ... -
Florbetapir F 18 amyloid PET and 36-month cognitive decline:a prospective multicenter study
(Nature Publishing Group, 2014)This study was designed to evaluate whether subjects with amyloid beta (Aβ) pathology, detected using florbetapir positron emission tomorgraphy (PET), demonstrated greater cognitive decline than subjects without Aβ pathology. ... -
Flotillin-2 Modulates Fas Signaling Mediated Apoptosis after Hyperoxia in Lung Epithelial Cells
(Public Library of Science, 2013)Lipid rafts are subdomains of the cell membrane with distinct protein composition and high concentrations of cholesterol and glycosphingolipids. Raft proteins are thought to mediate diverse cellular processes including ... -
Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in MiceNovelty and Significance
(Ovid Technologies (Wolters Kluwer Health), 2017) -
Flow-induced HDAC1 phosphorylation and nuclear export in angiogenic sprouting
(Nature Publishing Group, 2016)Angiogenesis requires the coordinated growth and migration of endothelial cells (ECs), with each EC residing in the vessel wall integrating local signals to determine whether to remain quiescent or undergo morphogenesis. ... -
Flow-induced protein kinase A–CREB pathway acts via BMP signaling to promote HSC emergence
(The Rockefeller University Press, 2015)Fluid shear stress promotes the emergence of hematopoietic stem cells (HSCs) in the aorta–gonad–mesonephros (AGM) of the developing mouse embryo. We determined that the AGM is enriched for expression of targets of protein ... -
Flt3L-dependence helps define an uncharacterized subset of murine cutaneous dendritic cells
(2014)Skin-derived dendritic cells (DC) are potent antigen presenting cells with critical roles in both adaptive immunity and tolerance to self. Skin DC carry antigens and constitutively migrate to the skin draining lymph nodes ... -
Flu Near You: An Online Self-reported Influenza Surveillance System in the USA
(University of Illinois at Chicago Library, 2013)Objective: To develop a participatory system for monitoring the activity of influenza-like-illness among the United States general population. Introduction: The emergence of new influenza strains including H1N1, H5N1, H3N2v ... -
Fludarabine add-on therapy in interferon-beta-treated patients with multiple sclerosis experiencing breakthrough disease
(SAGE Publications, 2016)Background: Patients with relapsing–remitting multiple sclerosis (RRMS) may experience breakthrough disease despite effective interferon beta (IFNβ) therapy. Fludarabine (FLU) is a chemotherapeutic agent used in ... -
Fluid intelligence and brain functional organization in aging yoga and meditation practitioners
(Frontiers Media S.A., 2014)Numerous studies have documented the normal age-related decline of neural structure, function, and cognitive performance. Preliminary evidence suggests that meditation may reduce decline in specific cognitive domains and ... -
Fluid Retention Associated with Imatinib Treatment in Patients with Gastrointestinal Stromal Tumor: Quantitative Radiologic Assessment and Implications for Management
(The Korean Society of Radiology, 2015)Objective: We aimed to describe radiologic signs and time-course of imatinib-associated fluid retention (FR) in patients with gastrointestinal stromal tumor (GIST), and its implications for management. Materials and Methods ... -
Fluidization and Resolidification of the Human Bladder Smooth Muscle Cell in Response to Transient Stretch
(Public Library of Science, 2010)Background: Cells resident in certain hollow organs are subjected routinely to large transient stretches, including every adherent cell resident in lungs, heart, great vessels, gut, and bladder. We have shown recently that ... -
FluKB: A Knowledge-Based System for Influenza Vaccine Target Discovery and Analysis of the Immunological Properties of Influenza Viruses
(Hindawi Publishing Corporation, 2015)FluKB is a knowledge-based system focusing on data and analytical tools for influenza vaccine discovery. The main goal of FluKB is to provide access to curated influenza sequence and epitope data and enhance the analysis ... -
Fluorescence activated enrichment of CD146+ cells during expansion of human bone-marrow derived mesenchymal stromal cells augments proliferation and GAG/DNA content in chondrogenic media
(BioMed Central, 2014)Background: While numerous subpopulations of BM-MSCs have been identified, the relevance of these findings regarding the functional properties remains mostly unclear. With regards to attempts of enhancing differentiation ... -
Fluorescence Endoscopy of Cathepsin Activity Discriminates Dysplasia from Colitis
(Oxford University Press, 2013)Background:Surveillance colonoscopy using random biopsies to detect colitis-associated cancer (CAC) suffers from poor sensitivity. Although chromoendoscopy improves detection, acceptance in the community has been slow. ...