Browsing Harvard Medical School by Title
Now showing items 6851-6870 of 18428
-
GC-rich sequence elements recruit PRC2 in mammalian ES cells
(Public Library of Science, 2010)Polycomb proteins are epigenetic regulators that localize to developmental loci in the early embryo where they mediate lineage-specific gene repression. In Drosophila, these repressors are recruited to sequence elements ... -
Gd(DOTAlaP): Exploring the Boundaries of Fast Water Exchange in Gadolinium-Based Magnetic Resonance Imaging Contrast Agents
(American Chemical Society, 2014)Here, we describe the synthesis of the single amino acid chelator DOTAlaP and four of its derivatives. The corresponding gadolinium(III) complexes were investigated for their kinetic inertness, relaxometric properties at ... -
Ge-1 is a central component of the mammalian cytoplasmic mRNA processing body
(Cold Spring Harbor Laboratory Press, 2005)The mRNA processing body (P-body) is a cellular structure that regulates gene expression by degrading cytoplasmic mRNA. The objective of this study was to identify and characterize novel components of the mammalian P-body. ... -
GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses
(2014)Detailed understanding of the signaling intermediates that confer the sensing of intracellular viral nucleic acids for induction of type I interferons is critical for strategies to curtail viral mechanisms that impede ... -
GEF-H1 Mediated Control of NOD1 Dependent NF-κB Activation by Shigella Effectors
(Public Library of Science, 2008)Shigella flexneri has evolved the ability to modify host cell function with intracellular active effectors to overcome the intestinal barrier. The detection of these microbial effectors and the initiation of innate immune ... -
Gefitinib and High-Dose Fractionated Radiotherapy for Carcinomatous Encephalitis from Non-Small Cell Lung Carcinoma
(Dove Medical Press, 2007)Carcinomatous encephalitis is a rapidly fatal form of metastasis caused by miliary spread of systemic cancer into the brain parenchyma. The diagnostic criteria and optimal treatment for this disease are not well defined. ... -
Gelsolin and Progression of Aortic Arch Calcification in Chronic Hemodialysis Patients
(Ivyspring International Publisher, 2016)Background:Vascular calcification (VC) is a key process associated with cardiovascular mortality in dialysis patients. Gelsolin is an actin-binding protein that can modulate inflammation, correlated inversely with hemodialysis ... -
Gem1 and ERMES Do Not Directly Affect Phosphatidylserine Transport from ER to Mitochondria or Mitochondrial Inheritance
(Blackwell Publishing Ltd, 2012)In yeast, a protein complex termed the ER-Mitochondria Encounter Structure (ERMES) tethers mitochondria to the endoplasmic reticulum. ERMES proteins are implicated in a variety of cellular functions including phospholipid ... -
GEMINI: Integrative Exploration of Genetic Variation and Genome Annotations
(Public Library of Science, 2013)Modern DNA sequencing technologies enable geneticists to rapidly identify genetic variation among many human genomes. However, isolating the minority of variants underlying disease remains an important, yet formidable ... -
Gender and racial/ethnic differences in the associations of urinary phthalate metabolites with markers of diabetes risk: national health and nutrition examination survey 2001–2008
(BioMed Central, 2014)Background: Phthalates are ubiquitous endocrine disrupting chemicals associated with diabetes. Although women and minorities are more likely to be exposed to phthalates, no prior studies have examined phthalate exposure ... -
Gender and vocal production mode discrimination using the high frequencies for speech and singing
(Frontiers Media S.A., 2014)Humans routinely produce acoustical energy at frequencies above 6 kHz during vocalization, but this frequency range is often not represented in communication devices and speech perception research. Recent advancements ... -
Gender difference in motor impairments induced by chronic administration of vinblastine
(Mashhad University of Medical Sciences, 2014)Objective(s): Neurotoxicity of anticancer drugs complicates treatment of cancer patients. Vinblastine (VBL) is reported to induce motor and cognitive impairments in patients receiving chronic low-dose regimen. Materials ... -
Gender Differences in Real-Home Sleep of Young and Older Couples
(Southwest Journal of Pulmonary and Critical Care, 2015)Objectives: To understand gender differences in sleep quality, architecture and duration of young healthy couples in comparison to older couples in their natural sleep environment. Design: Sleep was monitored in a naturalistic ... -
Gender Differences in Somatic Symptoms and Current Suicidal Risk in Outpatients with Major Depressive Disorder
(Korean Neuropsychiatric Association, 2016)Objective: Although somatic symptoms are common complaints of patients with major depressive disorder (MDD), their associations with suicide are still unclear. Methods: A total of 811 MDD outpatients of aged between 18 to ... -
Gender Differences in Sustained Attentional Control Relate to Gender Inequality across Countries
(Public Library of Science, 2016)Sustained attentional control is critical for everyday tasks and success in school and employment. Understanding gender differences in sustained attentional control, and their potential sources, is an important goal of ... -
Gender Differences in the Motivational Processing of Babies Are Determined by Their Facial Attractiveness
(Public Library of Science, 2009)Background: This study sought to determine how esthetic appearance of babies may affect their motivational processing by the adults. Methodology and Principal Findings: Healthy men and women were administered two ... -
Gender Disparity and Mutation Burden in Melanoma
(2016-05-17)A female advantage in melanoma incidence and outcome has been consistently observed but remains unexplained. We hypothesized that tumors are genetically distinct between men and women and analyzed the mutation spectra in ... -
Gender-Related Differences in the Prevalence of Cardiovascular Disease Risk Factors and their Correlates in Urban Tanzania
(BioMed Central, 2009)Background: Urban areas in Africa suffer a serious problem with dual burden of infectious diseases and emerging chronic diseases such as cardiovascular diseases (CVD) and diabetes which pose a serious threat to population ... -
Gender-specific hypertension and responsiveness to nitric oxide in sGCa1 knockout mice
(Oxford University Press (OUP), 2008)Aim: The effects of nitric oxide (NO) in the cardiovascular system are attributed in part to cGMP synthesis by the α1β1 isoform of soluble guanylate cyclase (sGC). Because available sGC inhibitors are neither enzyme- nor ...