Browsing Harvard Medical School by Title

Now showing items 7652-7671 of 18442

    • The hematopoietic stem cell niche 

      Park, Dongsu; Sykes, David Brian; Scadden, David Thomas (Frontiers in Bioscience, 2012)
      Hematopoietic stem cells (HSCs) possess the ability to self-renew and to differentiate to mature progeny along multiple different hematopoietic lineages. The function of HSCs depends upon the signals from surrounding cells ...

    • Hematopoietic Stem Cells, Hematopoiesis and Disease: Lessons from the Zebrafish Model 

      Martin, Corey S; Moriyama, Akemi; Zon, Leonard Ira (BioMed Central, 2011)
      The zebrafish model is rapidly gaining prominence in the study of development, hematopoiesis, and disease. The zebrafish provides distinct advantages over other vertebrate models during early embryonic development by ...

    • Hematopoietic Stem-Cell Transplantation in the Resource-Limited Setting: Establishing the First Bone Marrow Transplantation Unit in Bangladesh 

      Yeh, Albert; Khan, Mohiuddin; Harlow, Jason; Biswas, Akhil; Akter, Mafruha; Ferdous, Jannatul; Ara, Tasneem; Islam, Manirul; Caron, Martin; Barron, Anne-Marie; Moran, Jenna; Brezina, Mark; Nazneen, Humayra; Kamruzzaman, Md; Saha, Anup; Marshall, Ariela; Afrose, Salma; Stowell, Christopher; Preffer, Frederic; Bangsberg, David; Goodman, Annekathryn; Attar, Eyal; McAfee, Steven; Spitzer, Thomas; Dey, Bimalangshu (American Society of Clinical Oncology (ASCO), 2018)
      Purpose: Treatment of malignant and nonmalignant hematologic diseases with hematopoietic stem-cell transplantation (HSCT) was first described almost 60 years ago, and its use has expanded significantly over the last 20 ...

    • Heme deficiency of soluble guanylate cyclase induces gastroparesis 

      Cosyns, S. M. R.; Dhaese, I.; Thoonen, Robrecht; Buys, Emmanuel; Vral, A.; Brouckaert, P.; Lefebvre, R. A. (Wiley-Blackwell, 2013)
      Background: Soluble guanylate cyclase (sGC) is the principal target of nitric oxide (NO) to control gastrointestinal motility. The consequence on nitrergic signaling and gut motility of inducing a heme-free status of sGC, ...

    • Heme oxygenase-1 derived carbon monoxide permits maturation of myeloid cells 

      Wegiel, B; Hedblom, A; Li, M; Gallo, D; Csizmadia, E; Harris, C; Nemeth, Z; Zuckerbraun, B S; Soares, M; Persson, J L; Otterbein, L E (Nature Publishing Group, 2014)
      Critical functions of the immune system are maintained by the ability of myeloid progenitors to differentiate and mature into macrophages. We hypothesized that the cytoprotective gas molecule carbon monoxide (CO), generated ...

    • Heme oxygenase-1 in macrophages controls prostate cancer progression 

      Nemeth, Zsuzsanna; Li, Mailin; Csizmadia, Eva; Döme, Balazs; Johansson, Martin; Persson, Jenny Liao; Seth, Pankaj; Otterbein, Leo; Wegiel, Barbara (Impact Journals LLC, 2015)
      Innate immune cells strongly influence cancer growth and progression via multiple mechanisms including regulation of epithelial to mesenchymal transition (EMT). In this study, we investigated whether expression of the ...

    • Heme oxygenase-1-mediated neuroprotection in subarachnoid hemorrhage via intracerebroventricular deferoxamine 

      LeBlanc, Robert H.; Chen, Ruiya; Selim, Magdy H.; Hanafy, Khalid A. (BioMed Central, 2016)
      Background: Subarachnoid hemorrhage (SAH) is a devastating disease that affects over 30,000 Americans per year. Previous animal studies have explored the therapeutic effects of deferoxamine (DFX) via its iron-chelating ...

    • Hemichordate genomes and deuterostome origins 

      Simakov, Oleg; Kawashima, Takeshi; Marlétaz, Ferdinand; Jenkins, Jerry; Koyanagi, Ryo; Mitros, Therese; Hisata, Kanako; Bredeson, Jessen; Shoguchi, Eiichi; Gyoja, Fuki; Yue, Jia-Xing; Chen, Yi-Chih; Freeman, Robert M.; Sasaki, Akane; Hikosaka-Katayama, Tomoe; Sato, Atsuko; Fujie, Manabu; Baughman, Kenneth W.; Levine, Judith; Gonzalez, Paul; Cameron, Christopher; Fritzenwanker, Jens H.; Pani, Ariel M.; Goto, Hiroki; Kanda, Miyuki; Arakaki, Nana; Yamasaki, Shinichi; Qu, Jiaxin; Cree, Andrew; Ding, Yan; Dinh, Huyen H.; Dugan, Shannon; Holder, Michael; Jhangiani, Shalini N.; Kovar, Christie L.; Lee, Sandra L.; Lewis, Lora R.; Morton, Donna; Nazareth, Lynne V.; Okwuonu, Geoffrey; Santibanez, Jireh; Chen, Rui; Richards, Stephen; Muzny, Donna M.; Gillis, Andrew; Peshkin, Leonid; Wu, Michael; Humphreys, Tom; Su, Yi-Hsien; Putnam, Nicholas H.; Schmutz, Jeremy; Fujiyama, Asao; Yu, Jr-Kai; Tagawa, Kunifumi; Worley, Kim C.; Gibbs, Richard A.; Kirschner, Marc W.; Lowe, Christopher J.; Satoh, Noriyuki; Rokhsar, Daniel S.; Gerhart, John (2015)
      Acorn worms, also known as enteropneust (literally, ‘gut-breathing’) hemichordates, are marine invertebrates that share features with echinoderms and chordates. Together, these three phyla comprise the deuterostomes. Here ...

    • Hemispheric Biases and the Control of Visuospatial Attention: An ERP Study 

      Spencer, Kevin M.; Banich, Marie T (BioMed Central, 2005)
      Background: We examined whether individual differences in hemispheric utilization can interact with the intrinsic attentional biases of the cerebral hemispheres. Evidence suggests that the hemispheres have competing biases ...

    • Hemizygous Deletion on Chromosome 3p26.1 Is Associated with Heavy Smoking among African American Subjects in the COPDGene Study 

      Begum, Ferdouse; Ruczinski, Ingo; Hokanson, John E.; Lutz, Sharon M.; Parker, Margaret M.; Cho, Michael H.; Hetmanski, Jacqueline B.; Scharpf, Robert B.; Crapo, James D.; Silverman, Edwin K.; Beaty, Terri H. (Public Library of Science, 2016)
      Many well-powered genome-wide association studies have identified genetic determinants of self-reported smoking behaviors and measures of nicotine dependence, but most have not considered the role of structural variants, ...

    • Hemodynamic Environments from Opposing Sides of Human Aortic Valve Leaflets Evoke Distinct Endothelial Phenotypes In Vitro 

      Weinberg, Eli J.; Mack, Peter J.; Schoen, Frederick Jack; García-Cardeña, Guillermo; Kaazempur Mofrad, Mohammad R. (Springer US, 2010)
      The regulation of valvular endothelial phenotypes by the hemodynamic environments of the human aortic valve is poorly understood. The nodular lesions of calcific aortic stenosis (CAS) develop predominantly beneath the ...

    • Hemodynamic Impact of a Spontaneous Cervical Dissection on an Ipsilateral Saccular Aneurysm 

      See, Alfred P.; Gross, Bradley A.; Penn, David L.; Du, Rose; Frerichs, Kai U (Korean Society of Cerebrovascular Surgeons; Society of Korean Endovascular Neurosurgeons, 2016)
      The dynamic, hemodynamic impact of a cervical dissection on an ipsilateral, intracranial saccular aneurysm has not been well illustrated. This 45-year-old female was found to have a small, supraclinoid aneurysm ipsilateral ...

    • Hemoglobin \(A_{1c}\) as a Predictor of Incident Diabetes 

      Cheng, Peiyao; Neugaard, Britta; Foulis, Philip; Conlin, Paul Richard (American Diabetes Association, 2011)
      Objective: Several studies have suggested that \(HbA_{1c}\) levels may predict incident diabetes. With new recommendations for use of \(HbA_{1c}\) in diagnosing diabetes, many patients with \(HbA_{1c}\) results below the ...

    • Hemoglobin A1c and Arterial and Ventricular Stiffness in Older Adults 

      Zieman, Susan J.; Kamineni, Aruna; Ix, Joachim H.; Barzilay, Joshua; Djoussé, Luc; Kizer, Jorge R.; Biggs, Mary L.; de Boer, Ian H.; Chonchol, Michel; Gottdiener, John S.; Selvin, Elizabeth; Newman, Anne B.; Kuller, Lewis H.; Siscovick, David S.; Mukamal, Kenneth J. (Public Library of Science, 2012)
      Objective: Arterial and ventricular stiffening are characteristics of diabetes and aging which confer significant morbidity and mortality; advanced glycation endproducts (AGE) are implicated in this stiffening pathophysiology. ...

    • Hemoglobin A1c Is Associated With Increased Risk of Incident Coronary Heart Disease Among Apparently Healthy, Nondiabetic Men and Women 

      Pai, Jennifer; Cahill, Leah; Hu, Frank B.; Rexrode, Kathryn Marian; Manson, JoAnn Elisabeth; Rimm, Eric B. (Blackwell Publishing Ltd, 2013)
      Background: Hemoglobin A1c (HbA1c), a time‐integrated marker of glycemic control, predicts risk of coronary heart disease (CHD) among diabetics. Few studies have examined HbA1c and risk of CHD among women and men without ...

    • Hemoglobin A1c Levels and Aortic Arterial Stiffness: The Cardiometabolic Risk in Chinese (CRC) Study 

      Liang, Jun; Zhou, Na; Teng, Fei; Zou, Caiyan; Xue, Ying; Yang, Manqing; Song, Huaidong; Qi, Lu (Public Library of Science, 2012)
      Objective: The American Diabetes Association (ADA) recently published new clinical guidelines in which hemoglobin A1c (HbA1c) was recommended as a diagnostic test for diabetes. The present study was to investigate the ...

    • Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasis 

      Core, Amanda B.; Canali, Susanna; Babitt, Jodie L. (Frontiers Media S.A., 2014)
      Mutations in hemojuvelin (HJV) are the most common cause of the juvenile-onset form of the iron overload disorder hereditary hemochromatosis. The discovery that HJV functions as a co-receptor for the bone morphogenetic ...

    • Hemopexin in severe inflammation and infection: mouse models and human diseases 

      Lin, Tian; Maita, Dayana; Thundivalappil, Sujatha R; Riley, Frank E; Hambsch, Jasmin; Van Marter, Linda J; Christou, Helen A; Berra, Lorenzo; Fagan, Shawn; Christiani, David C; Warren, H Shaw (BioMed Central, 2015)
      Introduction: Cell-free plasma hemoglobin is associated with poor outcome in patients with sepsis. Extracellular hemoglobin and secondarily released heme amplify inflammation in the presence of microbial TLR ligands and/or ...

    • Hemorrhage After Manual Removal of the Placenta: Weighing Risk Factors and the Role of the Third Stage of Labor 

      Perlman, Nicola (2018-05-15)
      Introduction: Manual removal of the placenta, often due to uterine atony or an abnormally adherent placenta, can be accompanied by severe maternal postpartum hemorrhage. The objective of this study was to identify risk ...

    • Hemorrhage from Extra-Antral Gastric Antral Vascular Ectasia in a Patient with Duodenal Heterotopic Gastric Mucosa 

      Gubatan, John; Raines, Nathan; Khosravi, Hasan; Challies, Tracy L.; Berzin, Tyler M. (Hindawi Publishing Corporation, 2016)
      Gastric antral vascular ectasias (GAVE) have been increasingly recognized as an uncommon cause of chronic gastrointestinal bleeding and anemia, although their underlying pathogenesis is not completely well understood. ...