Browsing Harvard Medical School by Title
Now showing items 18384-18403 of 18442
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YAP Subcellular Localization and Hippo Pathway Transcriptome Analysis in Pediatric Hepatocellular Carcinoma
(Nature Publishing Group, 2016)Pediatric hepatocellular carcinoma (HCC) is a rare tumor which is associated with an extremely high mortality rate due to lack of effective chemotherapy. Recently, the Hippo pathway and its transcriptional co-activator ... -
A YAP/TAZ-miR-130/301 molecular circuit exerts systems-level control of fibrosis in a network of human diseases and physiologic conditions
(Nature Publishing Group, 2015)The molecular origins of fibrosis affecting multiple tissue beds remain incompletely defined. Previously, we delineated the critical role of the control of extracellular matrix (ECM) stiffening by the mechanosensitive ... -
YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression
(Oxford University Press, 2016)Stress-induced angiogenin (ANG)-mediated tRNA cleavage promotes a cascade of cellular events that starts with production of tRNA-derived stress-induced RNAs (tiRNAs) and culminates with enhanced cell survival. This stress ... -
Years of Able Life in Older Persons—The Role of Cardiovascular Imaging and Biomarkers: The Cardiovascular Health Study
(Blackwell Publishing Ltd, 2015)Background: As the U.S. population grows older, there is greater need to examine physical independence. Previous studies have assessed risk factors in relation to either disability or mortality, but an outcome that combines ... -
A Yeast Model of FUS/TLS-Dependent Cytotoxicity
(Public Library of Science, 2011)FUS/TLS is a nucleic acid binding protein that, when mutated, can cause a subset of familial amyotrophic lateral sclerosis (fALS). Although FUS/TLS is normally located predominantly in the nucleus, the pathogenic mutant ... -
Yeast Oligo-mediated Genome Engineering (YOGE)
(American Chemical Society, 2013-12-20)High-frequency oligonucleotide-directed recombination engineering (recombineering) has enabled rapid modification of several prokaryotic genomes to date. Here, we present a method for oligonucleotide-mediated recombineering ... -
The Yield of Head CT in Syncope: A Pilot Study
(Springer-Verlag, 2007)Although head CT is often routinely performed in emergency department (ED) patients with syncope, few studies have assessed its value. Objectives: To determine the yield of routine head CT in ED patients with syncope and ... -
The Yin and the Yang of Prediction: An fMRI Study of Semantic Predictive Processing
(Public Library of Science, 2016)Probabilistic prediction plays a crucial role in language comprehension. When predictions are fulfilled, the resulting facilitation allows for fast, efficient processing of ambiguous, rapidly-unfolding input; when predictions ... -
yMGV: A Cross-Species Expression Data Mining Tool
(Oxford University Press (OUP), 2004-01-01)The yeast Microarray Global Viewer (yMGV @ http://transcriptome.ens.fr/ymgv) was created 3 years ago as a database that houses a collection of Saccharomyces cerevisiae and Schizosaccharo myces pombe microarray data sets ... -
Yoga as a Therapeutic Intervention
(Hindawi Publishing Corporation, 2012) -
Yohimbine-Induced Amygdala Activation in Pathological Gamblers: A Pilot Study
(Public Library of Science, 2012)Rationale and Objectives: There is evidence that drug addiction is associated with increased physiological and psychological responses to stress. In this pilot functional magnetic resonance imaging (fMRI) study we assessed ... -
“You're never really off time”: Healthcare providers' interpretations of optimal timing for HPV vaccination
(Elsevier, 2016)Healthcare providers have a strong influence on human papillomavirus (HPV) vaccination decisions, yet they often fail to recommend the vaccine to the 11- and 12-year-olds who are targeted by practice guidelines. We sought ... -
Young Adult Donor Bone Marrow Infusions into Female Mice Postpone Age-Related Reproductive Failure and Improve Offspring Survival
(Impact Journals LLC, 2009)The female reproductive axis is the first major organ system of the body to fail with advancing age. In addition to a permanent cessation of fertile potential, the loss of cyclic ovarian function in humans heralds the onset ... -
Young Adult Perspectives on a Successful Transition from Pediatric to Adult Care in Sickle Cell Disease
(2016)Objective: This qualitative study sought to learn from young adults with sickle cell disease (SCD) about their experience leaving pediatric care and perspective on what makes a successful transition. Methods: Fifteen young ... -
Young Adults, Social Networks, and Addiction Recovery: Post Treatment Changes in Social Ties and Their Role as a Mediator of 12-Step Participation
(Public Library of Science, 2014)Background: Social factors play a key role in addiction recovery. Research with adults indicates individuals with substance use disorder (SUD) benefit from mutual-help organizations (MHOs), such as Alcoholics Anonymous, ... -
Young Hispanic Women Experience Higher In-Hospital Mortality Following an Acute Myocardial Infarction
(John Wiley & Sons, Ltd, 2015)Background: Although mortality rates for acute myocardial infarction (AMI) have declined for men and women, prior studies have reported a sex gap in mortality such that younger women were most likely to die after an AMI. ... -
Young Hispanics at risk of type 2 diabetes display endothelial activation, subclinical inflammation and alterations of coagulation and fibrinolysis
(BioMed Central, 2013)Background: Hispanics have a high rate of diabetes that exposes them to an increased risk of cardiovascular disease. We hypothesized that many of the pathophysiological mechanisms that cause atherosclerotic disease may be ... -
Young professionals for health development: the Kenyan experience in combating non-communicable diseases
(Co-Action Publishing, 2013)Young individuals (below 35 years) comprise an estimated 60% of the global population. Not only are these individuals currently experiencing chronic, non-communicable diseases (NCDs), either living with or at risk for these ... -
Young systemic factors as a medicine for age-related neurodegenerative diseases
(Taylor & Francis, 2015)It is widely known that neurogenesis, brain function and cognition decline with aging. Increasing evidence suggests that cerebrovascular dysfunction is a major cause of cognitive impairment in the elderly but is also ... -
Your Father and Grandfather's Atrial Fibrillation: A Review of the Genetics of the Most Common Pathologic Cardiac Dysrhythmia
(Bentham Science Publishers, 2015)Atrial fibrillation (AF) remains the most common pathologic dysrhythmia in humans with a prevalence of 1-2% of the total population and as high as 10% of the elderly. AF is an independent risk marker for cardiovascular ...