Browsing Harvard Medical School by Title
Now showing items 4444-4463 of 18442
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Differential Gene Expression in the Developing Lateral Geniculate Nucleus and Medial Geniculate Nucleus Reveals Novel Roles for Zic4 and Foxp2 in Visual and Auditory Pathway Development
(Society for Neuroscience, 2009)Primary sensory nuclei of the thalamus process and relay parallel channels of sensory input into the cortex. The developmental processes by which these nuclei acquire distinct functional roles are not well understood. To ... -
Differential hRad17 Expression by Histologic Subtype of Ovarian Cancer
(BioMed Central, 2011)Background: In the search for unique ovarian cancer biomarkers, ovarian specific cDNA microarray analysis identified hRad17, a cell cycle checkpoint protein, as over-expressed in ovarian cancer. The aim of this study was ... -
Differential Levels of Soluble Inflammatory Markers by Human Immunodeficiency Virus Controller Status and Demographics
(Oxford University Press, 2014)Background. Human immunodeficiency virus (HIV)-1 elite controllers (ECs) represent an ideal population to study the effects of HIV persistence on chronic inflammation in the absence of antiretroviral therapy (ART). Methods. ... -
Differential Localization of mRNAs of Collagen Types I and II in Chick Fibroblasts, Chondrocytes, and Corneal Cells by In Situ Hybridization Using cDNA Probes
(Rockefeller University Press, 1986-06-01)We have employed a highly specific in situ hybridization protocol that allows differential detection of mRNAs of collagen types I and II in paraffin sections from chick embryo tissues. All probes were cDNA restriction ... -
Differential marker expression by cultures rich in mesenchymal stem cells
(BioMed Central, 2013)Background: Mesenchymal stem cells have properties that make them amenable to therapeutic use. However, the acceptance of mesenchymal stem cells in clinical practice requires standardized techniques for their specific ... -
Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells
(Dove Medical Press, 2014)Paclitaxel (Taxol) resistance remains a major obstacle for the successful treatment of ovarian cancer. MicroRNAs (miRNAs) have oncogenic and tumor suppressor activity and are associated with poor prognosis phenotypes. miRNA ... -
Differential PfEMP1 Expression Is Associated with Cerebral Malaria Pathology
(Public Library of Science, 2014)Plasmodium falciparum is unique among human malarias in its ability to sequester in post-capillary venules of host organs. The main variant antigens implicated are the P. falciparum erythrocyte membrane protein 1 (PfEMP1), ... -
Differential Pharmacological Effects on Brain Reactivity and Plasticity in Alzheimer’s Disease
(Frontiers Media S.A., 2013)Acetylcholinesterase inhibitors (AChEIs) are the most commonly prescribed monotherapeutic medications for Alzheimer’s disease (AD). However, their underlying neurophysiological effects remain largely unknown. We investigated ... -
Differential psychophysiological interactions of insular subdivisions during varied oropharyngeal swallowing tasks
(Wiley Periodicals, Inc., 2014)Abstract The insula is a highly integrated cortical region both anatomically and functionally. It has been shown to have cognitive, social–emotional, gustatory, and sensorimotor functions. Insular involvement in both normal ... -
Differential Recovery of Glycosaminoglycan After IL-1-Induced Degradation of Bovine Articular Cartilage Depends on Degree of Degradation
(BioMed Central, 2003)In the present study we examined cartilage matrix repair following IL-1-induced matrix depletion. Previous data indicated that, in some cases, chondrocytes can synthesize macromolecules to establish a functional extracellular ... -
Differential Recruitment of Dishevelled Provides Signaling Specificity in the Planar Cell Polarity and Wingless Signaling Pathways
(Cold Spring Harbor Laboratory, 1998-08-15)In Drosophila, planar cell polarity (PCP) signaling is mediated by the receptor Frizzled (Fz) and transduced by Dishevelled (Dsh). Wingless (Wg) signaling also requires Dsh and may utilize DFz2 as a receptor. Using a ... -
Differential Regulation of Cysteinyl Leukotriene Receptor Signaling by Protein Kinase C in Human Mast Cells
(Public Library of Science, 2013)Cysteinyl leukotrienes (cys-LTs) are a group of lipid mediators that are potent bronchoconstrictors, powerful inducers of vascular leakage and potentiators of airway hyperresponsiveness. Cys-LTs play an essential role in ... -
Differential regulation of mesodermal gene expression by Drosophila cell type-specific Forkhead transcription factors
(Company of Biologists, 2012)A common theme in developmental biology is the repeated use of the same gene in diverse spatial and temporal domains, a process that generally involves transcriptional regulation mediated by multiple separate enhancers, ... -
Differential regulation of myeloid leukemias by the bone marrow microenvironment
(2013)Like their normal hematopoietic stem cell counterparts, leukemia stem cells (LSC) in chronic myelogenous leukemia (CML) and acute myeloid leukemia (AML) are presumed to reside in specific niches in the bone marrow ... -
Differential regulation of neurexin at glutamatergic and GABAergic synapses
(Frontiers Media S.A., 2013)Neurexins (Nrxs) have emerged as potential determinants of synaptic specificity, but little is known about their localization at central synapses. Here we show that Nrxs have a remarkably selective localization at distinct ... -
Differential Requirement for PBP1a and PBP1b in in Vivo and in Vitro Fitness of Vibrio cholerae
(American Society for Microbiology, 2014)We investigated the roles of the Vibrio cholerae high-molecular-weight bifunctional penicillin binding proteins, PBP1a and PBP1b, in the fitness of this enteric pathogen. Using a screen for synthetic lethality, we found ... -
Differential responses to high-frequency electrical stimulation in ON and OFF retinal ganglion cells
(IOP Publishing, 2014-02-21)Objective The field of retinal prosthetics for artificial vision has advanced considerably in recent years, however clinical outcomes remain inconsistent. The performance of retinal prostheses is likely limited by the ... -
Differential Risk of Death in Older Residents in Nursing Homes Prescribed Specific Antipsychotic Drugs: Population Based Cohort Study
(BMJ Publishing Group Ltd., 2012)Objective: To assess risks of mortality associated with use of individual antipsychotic drugs in elderly residents in nursing homes. Design Population based cohort study with linked data from Medicaid, Medicare, the Minimum ... -
Differential role of nonhomologous end joining factors in the generation, DNA damage response, and myeloid differentiation of human induced pluripotent stem cells
(National Academy of Sciences, 2014)Nonhomologous end-joining (NHEJ) is a key pathway for efficient repair of DNA double-strand breaks (DSBs) and V(D)J recombination. NHEJ defects in humans cause immunodeficiency and increased cellular sensitivity to ionizing ...