Browsing Harvard Medical School by Title

Now showing items 6544-6563 of 18448

    • Fluorescence Endoscopy of Cathepsin Activity Discriminates Dysplasia from Colitis 

      Gounaris, Elias; Martin, John; Ishihara, Yasushige; Khan, Mohammad Wasim; Lee, Goo; Sinh, Preetika; Chen, Eric Zongming; Angarone, Michael; Weissleder, Ralph; Khazaie, Khasharyasha; Barrett, Terrence A. (Oxford University Press, 2013)
      Background:Surveillance colonoscopy using random biopsies to detect colitis-associated cancer (CAC) suffers from poor sensitivity. Although chromoendoscopy improves detection, acceptance in the community has been slow. ...

    • Fluorescence imaging with near-infrared light: New technological advances that enable in vivo molecular imaging 

      Ntziachristos, Vasilis; Bremer, Christoph; Weissleder, Ralph (Springer Verlag, 2003)
      A recent development in biomedical imaging is the non-invasive mapping of molecular events in intact tissues using fluorescence. Underpinning to this development is the discovery of bio-compatible, specific fluorescent ...

    • Fluorescence polarization-based nucleic acid testing for rapid and cost-effective diagnosis of infectious disease 

      Park, Ki Soo; Charles, Richelle; Ryan, Edward; Weissleder, Ralph; Lee, Hakho (Wiley, 2015)
      A new nucleic acid detection method was developed for a rapid and cost-effective diagnosis of infectious disease. This approach relies on the three unique elements: 1)detection probes that regulate DNA polymerase activity ...

    • Fluorescent Exendin-4 Derivatives for Pancreatic β-Cell Analysis 

      Clardy, Susan M.; Keliher, Edmund J.; Mohan, James F.; Sebas, Matt; Benoist, Christophe; Mathis, Diane; Weissleder, Ralph (American Chemical Society, 2014)

    • Fluorescent in situ sequencing (FISSEQ) of RNA for gene expression profiling in intact cells and tissues 

      Lee, Je Hyuk; Daugharthy, Evan R; Scheiman, Jonathan; Kalhor, Reza; Ferrante, Thomas Charles; Terry, Richard; Turczyk, Brian M; Yang, Joyce L; Lee, Ho Suk; Aach, John Dennis; Zhang, Kun; Church, George McDonald (Springer Nature, 2015)
      RNA sequencing measures the quantitative change in gene expression over the whole transcriptome, but it lacks spatial context. On the other hand, in situ hybridization provides the location of gene expression, but only for ...

    • Fluorescent Oxidation Products and Risk of Coronary Heart Disease: A Prospective Study in Women 

      Jensen, Majken K.; Wang, Yushan; Rimm, Eric B.; Townsend, Mary K.; Willett, Walter; Wu, Tianying (Blackwell Publishing Ltd, 2013)
      Background: Oxidative stress is implicated in the etiology of coronary heart disease (CHD). New measures to capture oxidative stress are warranted. Fluorescent oxidation products (FlOPs) can be measured in plasma and have ...

    • Fluorescent Vinblastine Probes for Live Cell Imaging 

      Meimetis, Labros G.; Giedt, Randy J.; Mikula, Hannes; Carlson, Jonathan C.; Kohler, Rainer; Pirovich, David B.; Weissleder, Ralph (Royal Society of Chemistry (RSC), 2016)
      Herein we describe the synthesis of several fluorescent analogues of the clinically approved microtubule destabilizing agent vinblastine. The evaluated probes are the most potent described and provides the first example ...

    • Fluoroquinolones Protective against Cephalosporin Resistance in Gram-Negative Nosocomial Pathogens 

      Schwaber, Mitchell J.; Cosgrove, Sara E.; Gold, Howard Seth; Kaye, Keith S.; Carmeli, Yehuda (Centers for Disease Control and Prevention, 2004)
      In a matched case-control study, we studied the effect of prior receipt of fluoroquinolones on isolation of three third-generation cephalosporin-resistant gram-negative nosocomial pathogens. Two hundred eighty-two cases ...

    • Fluorous Drug-Affinity Proteomics for Cancer Drug Discovery 

      Herzberg, Benjamin (2015-05-13)
      Identifying the intracellular targets of small molecules – target ID – is a major problem in chemical biology with broad application to the discovery and development of novel therapies. Traditional target ID studies have ...

    • FlyBase at 25: looking to the future 

      Gramates, L. Sian; Marygold, Steven J.; dos Santos, Gilberto; Urbano, Jose-Maria; Antonazzo, Giulia; Matthews, Beverley B.; Rey, Alix J.; Tabone, Christopher J.; Crosby, Madeline A.; Emmert, David B.; Falls, Kathleen; Goodman, Joshua L.; Hu, Yanhui; Ponting, Laura; Schroeder, Andrew J.; Strelets, Victor B.; Thurmond, Jim; Zhou, Pinglei (Oxford University Press, 2017)
      Since 1992, FlyBase (flybase.org) has been an essential online resource for the Drosophila research community. Concentrating on the most extensively studied species, Drosophila melanogaster, FlyBase includes information ...

    • FlyRNAi.org—the database of the Drosophila RNAi screening center and transgenic RNAi project: 2017 update 

      Hu, Yanhui; Comjean, Aram; Roesel, Charles; Vinayagam, Arunachalam; Flockhart, Ian; Zirin, Jonathan; Perkins, Lizabeth; Perrimon, Norbert; Mohr, Stephanie E. (Oxford University Press, 2017)
      The FlyRNAi database of the Drosophila RNAi Screening Center (DRSC) and Transgenic RNAi Project (TRiP) at Harvard Medical School and associated DRSC/TRiP Functional Genomics Resources website (http://fgr.hms.harvard.edu) ...

    • FlyRNAi.org—The Database of the Drosophila RNAi Screening Center: 2012 Update 

      Flockhart, Ian; Booker, Matthew; Hu, Yanhui; McElvany, Benjamin D; Gilly, Quentin Carl; Mathey-Prevot, Bernard; Perrimon, Norbert; Mohr, Stephanie (Oxford University Press, 2011)
      FlyRNAi (http://www.flyrnai.org), the database and website of the Drosophila RNAi Screening Center (DRSC) at Harvard Medical School, serves a dual role, tracking both production of reagents for RNA interference (RNAi) ...

    • FlyRNAi: the Drosophila RNAi screening center database 

      Flockhart, Ian; Booker, Matthew; Kiger, Amy; Boutros, Michael; Armknecht, Susan; Ramadan, Nadire; Richardson, Kris; Xu, Andrew; Perrimon, Norbert; Mathey-Prevot, Bernard (Oxford University Press, 2006)
      RNA interference (RNAi) has become a powerful tool for genetic screening in Drosophila. At the Drosophila RNAi Screening Center (DRSC), we are using a library of over 21 000 double-stranded RNAs targeting known and predicted ...

    • An fMRI study of semantic processing in men with schizophrenia 

      Kubicki, Marek R.; McCarley, Robert William; Nestor, Paul Gerard; Huh, T; Kikinis, Ron; Shenton, Martha Elizabeth; Wible, Cynthia Gayle (Elsevier BV, 2003)
      As a means toward understanding the neural bases of schizophrenic thought disturbance, we examined brain activation patterns in response to semantically and superficially encoded words in patients with schizophrenia. Nine ...

    • An fMRI study of unconditioned responses in post-traumatic stress disorder 

      Linnman, Clas; Zeffiro, Thomas A; Pitman, roger k; Milad, Mohammed Ragib (BioMed Central, 2011)
      Background: Both fear and pain processing are altered in post-traumatic stress disorder (PTSD), as evidenced by functional neuroimaging studies showing increased amygdala responses to threats, and increased insula, putamen ...

    • fMRI-compatible rehabilitation hand device 

      Khanicheh, Azadeh; Muto, Andrew; Triantafyllou, Christina; Weinberg, Brian; Astrakas, Loukas; Tzika, Aria; Mavroidis, Constantinos (BioMed Central, 2006)
      Background: Functional magnetic resonance imaging (fMRI) has been widely used in studying human brain functions and neurorehabilitation. In order to develop complex and well-controlled fMRI paradigms, interfaces that can ...

    • fMRI-DTI modeling via landmark distance atlases for prediction and detection of fiber tracts 

      O'Donnell, Lauren Jean; Rigolo, Laura; Norton, Isaiah; Wells, William Mercer; Westin, Carl-Fredrik; Golby, Alexandra Jacqueline (Elsevier BV, 2012)
      The overall goal of this research is the design of statistical atlas models that can be created from normal subjects, but may generalize to be applicable to abnormal brains. We present a new style of joint modeling of fMRI, ...

    • The FNIH Sarcopenia Project: Rationale, Study Description, Conference Recommendations, and Final Estimates 

      Studenski, Stephanie A.; Peters, Katherine W.; Alley, Dawn E.; Cawthon, Peggy M.; McLean, Robert R.; Harris, Tamara B.; Ferrucci, Luigi; Guralnik, Jack M.; Fragala, Maren S.; Kenny, Anne M.; Kiel, Douglas P.; Kritchevsky, Stephen B.; Shardell, Michelle D.; Dam, Thuy-Tien L.; Vassileva, Maria T. (Oxford University Press, 2014)
      Background. Low muscle mass and weakness are common and potentially disabling in older adults, but in order to become recognized as a clinical condition, criteria for diagnosis should be based on clinically relevant ...

    • Focal Adhesion Kinase Regulates Pathogen-Killing Capability and Life Span of Neutrophils via Mediating both Adhesion-Dependent and -Independent Cellular Signals 

      Kasorn, Anongnard; Alcaide, Pilar; Jia, Yonghui; Subramanian, Kulandayan K.; Sarraj, Bara; Li, Yitang; Loison, Fabien; Hattori, Hidenori; Silberstein, Leslie E.; Luscinskas, William F.; Luo, Hongbo (American Association of Immunologists, 2009)
      Various neutrophil functions such as phagocytosis, superoxide production, and survival are regulated by integrin signaling. Despite the essential role of focal adhesion kinase (FAK) in mediating this signaling pathway, its ...

    • Focally Enhanced Gastritis in Newly Diagnosed Pediatric Inflammatory Bowel Disease 

      Ushiku, Tetsuo; Moran, Christopher J; Lauwers, Gregory Y. (Ovid Technologies (Wolters Kluwer Health), 2013)
      Although the significance of focally enhanced gastritis (FEG) as a marker of Crohn disease (CD) in adults has been contested, several studies suggest that it may be more specific of CD in pediatric patients. This study ...