Browsing Harvard Medical School by Keyword "CPSF6"
Now showing items 1-2 of 2
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Spatial and Genomic Correlates of HIV-1 Integration Site Targeting
(MDPI AG, 2022-02-14)HIV-1 integrase and capsid proteins interact with host proteins to direct preintegration complexes to active transcription units within gene-dense regions of chromosomes for viral DNA integration. Analyses of spatially-derived ... -
Viral and Cellular Requirements for the Nuclear Entry of Retroviral Preintegration Nucleoprotein Complexes
(MDPI, 2013)Retroviruses integrate their reverse transcribed genomes into host cell chromosomes as an obligate step in virus replication. The nuclear envelope separates the chromosomes from the cell cytoplasm during interphase, and ...