Browsing Harvard Medical School by Keyword "inhibitory receptor"

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    • TIM3+FOXP3+ regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer 

      Sakuishi, Kaori; Ngiow, Shin Foong; Sullivan, Jenna M.; Teng, Michele W. L.; Kuchroo, Vijay K.; Smyth, Mark J.; Anderson, Ana C. (Landes Bioscience, 2013)
      T-cell immunoglobulin mucin 3 (TIM3) is an inhibitory molecule that has emerged as a key regulator of dysfunctional or exhausted CD8+ T cells arising in chronic diseases such as cancer. In addition to exhausted CD8+ T ...